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- W2890914954 abstract "African swine fever (ASF) is a pathology of pigs against which there is no treatment or vaccine. Understanding the equilibrium between innate and adaptive protective responses and immune pathology might contribute to the development of strategies against ASFV. Here we compare, using a proteomic approach, the course of the in vivo infection caused by two homologous strains: the virulent E75 and the attenuated E75CV1. Our results show a progressive loss of proteins by day 7 post-infection (pi) with E75, reflecting tissue destruction. Many signal pathways were affected by both infections but in different ways and extensions. Cytoskeletal remodelling and clathrin-endocytosis were affected by both isolates, while a greater number of proteins involved on inflammatory and immunological pathways were altered by E75CV1. 14-3-3 mediated signalling, related to immunity and apoptosis, was inhibited by both isolates. The implication of the Rho GTPases by E75CV1 throughout infection is also evident. Early events reflected the lack of E75 recognition by the immune system, an evasion strategy acquired by the virulent strains, and significant changes at 7 days post-infection (dpi), coinciding with the peak of infection and the time of death. The protein signature at day 31 pi with E75CV1 seems to reflect events observed at 1 dpi, including the upregulation of proteosomal subunits and molecules described as autoantigens (vimentin, HSPB1, enolase and lymphocyte cytosolic protein 1), which allow the speculation that auto-antibodies could contribute to chronic ASFV infections. Therefore, the use of proteomics could help understand ASFV pathogenesis and immune protection, opening new avenues for future research." @default.
- W2890914954 created "2018-09-27" @default.
- W2890914954 creator A5019560166 @default.
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- W2890914954 date "2018-09-12" @default.
- W2890914954 modified "2023-10-18" @default.
- W2890914954 title "Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains" @default.
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- W2890914954 cites W1492305306 @default.
- W2890914954 cites W1968437147 @default.
- W2890914954 cites W1974538638 @default.
- W2890914954 cites W1986723919 @default.
- W2890914954 cites W1990901852 @default.
- W2890914954 cites W1995892986 @default.
- W2890914954 cites W1996518201 @default.
- W2890914954 cites W1999007210 @default.
- W2890914954 cites W1999374300 @default.
- W2890914954 cites W2000041926 @default.
- W2890914954 cites W2003337475 @default.
- W2890914954 cites W2011386897 @default.
- W2890914954 cites W2011654163 @default.
- W2890914954 cites W2012019720 @default.
- W2890914954 cites W2013512540 @default.
- W2890914954 cites W2015753486 @default.
- W2890914954 cites W2016171668 @default.
- W2890914954 cites W2022258840 @default.
- W2890914954 cites W2024230085 @default.
- W2890914954 cites W2032196305 @default.
- W2890914954 cites W2035301267 @default.
- W2890914954 cites W2039653286 @default.
- W2890914954 cites W2041970910 @default.
- W2890914954 cites W2042209974 @default.
- W2890914954 cites W2042580154 @default.
- W2890914954 cites W2051789054 @default.
- W2890914954 cites W2055905951 @default.
- W2890914954 cites W2058875956 @default.
- W2890914954 cites W2065076530 @default.
- W2890914954 cites W2065360219 @default.
- W2890914954 cites W2066913567 @default.
- W2890914954 cites W2067117199 @default.
- W2890914954 cites W2068437949 @default.
- W2890914954 cites W2071591548 @default.
- W2890914954 cites W2076635920 @default.
- W2890914954 cites W2077563423 @default.
- W2890914954 cites W2080490788 @default.
- W2890914954 cites W2088809814 @default.
- W2890914954 cites W2091744461 @default.
- W2890914954 cites W2097494814 @default.
- W2890914954 cites W2107448615 @default.
- W2890914954 cites W2113518357 @default.
- W2890914954 cites W2123713120 @default.
- W2890914954 cites W2127749262 @default.
- W2890914954 cites W2128345370 @default.
- W2890914954 cites W2132615967 @default.
- W2890914954 cites W2134609748 @default.
- W2890914954 cites W2136129352 @default.
- W2890914954 cites W2136337426 @default.
- W2890914954 cites W2137799085 @default.
- W2890914954 cites W2144991158 @default.
- W2890914954 cites W2148884752 @default.
- W2890914954 cites W2152222091 @default.
- W2890914954 cites W2160852275 @default.
- W2890914954 cites W2162976896 @default.
- W2890914954 cites W2166227754 @default.
- W2890914954 cites W2176261673 @default.
- W2890914954 cites W2196772568 @default.
- W2890914954 cites W2307244008 @default.
- W2890914954 cites W2319666995 @default.
- W2890914954 cites W2322774517 @default.
- W2890914954 cites W2530435619 @default.
- W2890914954 cites W2566571644 @default.
- W2890914954 cites W2567661995 @default.
- W2890914954 cites W2571523209 @default.
- W2890914954 cites W2595738190 @default.
- W2890914954 cites W2613902351 @default.
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- W2890914954 doi "https://doi.org/10.1186/s13567-018-0585-z" @default.
- W2890914954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134756" @default.
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- W2890914954 hasPublicationYear "2018" @default.
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