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• W2890917627 abstract "An enriched environment protects dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury, but the underlying mechanism for this is not clear. Growth associated protein-43 (GAP-43) is closely associated with neurite outgrowth and axon regeneration during neural development. We speculate that an enriched environment can reduce damage to dopaminergic neurons by affecting the expression of GAP-43. This study is designed to test this hypothesis. Three-month-old female senescence-accelerated mouse prone 8 (SAMP8) mice were housed for 3 months in an enriched environment or a standard environment. These mice were then subcutaneously injected in the abdomen with 14 mg/kg MPTP four times at 2-hour intervals. Morris water maze testing demonstrated that learning and memory abilities were better in the enriched environment group than in the standard environment group. Reverse-transcription polymerase chain reaction, immunohistochemistry and western blot assays showed that mRNA and protein levels of GAP-43 in the substantia nigra were higher after MPTP application in the enriched environment group compared with the standard environment group. These findings indicate that an enriched environment can increase GAP-43 expression in SAMP8 mice. The upregulation of GAP-43 may be a mechanism by which an enriched environment protects against MPTP-induced neuronal damage." @default.
• W2890917627 created "2018-09-27" @default.
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• W2890917627 date "2018-01-01" @default.
• W2890917627 modified "2023-10-16" @default.
• W2890917627 title "Enriched environment elevates expression of growth associated protein-43 in the substantia nigra of SAMP8 mice" @default.
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• W2890917627 doi "https://doi.org/10.4103/1673-5374.239447" @default.
• W2890917627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6183044" @default.
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