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• W2890919276 endingPage "70" @default.
• W2890919276 startingPage "62" @default.
• W2890919276 abstract "Childhood absence epilepsy (CAE) is the most common pediatric epilepsy syndrome and is characterized by typical absence seizures (AS). AS are non-convulsive epileptic seizures characterized by a sudden loss of awareness and bilaterally generalized synchronous 2.5-4 Hz spike and slow-wave discharges (SWD). Gamma butyrolactone (GBL) is an acute pharmacological model of AS and induces bilaterally synchronous SWDs and behavioral arrest. Despite the long use of this model, little is known about its strain and sex-dependent features. We compared the dose-response profile of GBL-evoked SWDs in three rat strains (Long Evans, Sprague-Dawley, and Wistar), and examined the modulatory effects of estrous cycle on SWDs in female Wistar rats. We evaluated the number of seizures, the cumulative time seizing, and the average seizure duration as a function of dose, strain, and sex/estrous phase. Long Evans rats displayed the greatest sensitivity to GBL, followed by Wistar rats, and then by Sprague-Dawley rats. GBL-evoked SWDs were modulated by estrous cycle in female rats, with the lowest sensitivity to GBL occurring during metestrus. Wistar rats showed the greatest variability as a function of dose, and the least variability within dose; these features make this strain desirable for interventional studies. Moreover, our finding that the SWD response to GBL differs as a function of estrous cycle underscores the importance of cycle monitoring in studies examining female animals using this model. Together, these strain and sex-dependent findings provide guidance for future studies." @default.
• W2890919276 created "2018-09-27" @default.
• W2890919276 creator A5009944831 @default.
• W2890919276 creator A5036232159 @default.
• W2890919276 creator A5082341410 @default.
• W2890919276 creator A5086811651 @default.
• W2890919276 creator A5090011943 @default.
• W2890919276 date "2018-11-01" @default.
• W2890919276 modified "2023-10-10" @default.
• W2890919276 title "Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats" @default.
• W2890919276 cites W1214158774 @default.
• W2890919276 cites W1523685017 @default.
• W2890919276 cites W1545913212 @default.
• W2890919276 cites W1584575938 @default.
• W2890919276 cites W1640380312 @default.
• W2890919276 cites W1699958347 @default.
• W2890919276 cites W1806851391 @default.
• W2890919276 cites W1934916890 @default.
• W2890919276 cites W1951003854 @default.
• W2890919276 cites W1964203623 @default.
• W2890919276 cites W1964437684 @default.
• W2890919276 cites W1965584252 @default.
• W2890919276 cites W1967517460 @default.
• W2890919276 cites W1971779257 @default.
• W2890919276 cites W1972393602 @default.
• W2890919276 cites W1972649872 @default.
• W2890919276 cites W1974383888 @default.
• W2890919276 cites W1974708308 @default.
• W2890919276 cites W1975403442 @default.
• W2890919276 cites W1975986172 @default.
• W2890919276 cites W1977696445 @default.
• W2890919276 cites W1981823471 @default.
• W2890919276 cites W1984655410 @default.
• W2890919276 cites W1985693412 @default.
• W2890919276 cites W1987234012 @default.
• W2890919276 cites W1995755186 @default.
• W2890919276 cites W1996937028 @default.
• W2890919276 cites W2005497343 @default.
• W2890919276 cites W2008728377 @default.
• W2890919276 cites W2013777991 @default.
• W2890919276 cites W2016140176 @default.
• W2890919276 cites W2020626807 @default.
• W2890919276 cites W2022113624 @default.
• W2890919276 cites W2030113059 @default.
• W2890919276 cites W2031691658 @default.
• W2890919276 cites W2035291193 @default.
• W2890919276 cites W2037784091 @default.
• W2890919276 cites W2039341631 @default.
• W2890919276 cites W2039444589 @default.
• W2890919276 cites W2041068689 @default.
• W2890919276 cites W2042291251 @default.
• W2890919276 cites W2043304912 @default.
• W2890919276 cites W2055597757 @default.
• W2890919276 cites W2059979222 @default.
• W2890919276 cites W2064709197 @default.
• W2890919276 cites W2072774393 @default.
• W2890919276 cites W2072860222 @default.
• W2890919276 cites W2074270259 @default.
• W2890919276 cites W2079624598 @default.
• W2890919276 cites W2083567672 @default.
• W2890919276 cites W2084237876 @default.
• W2890919276 cites W2086659984 @default.
• W2890919276 cites W2087302134 @default.
• W2890919276 cites W2088393247 @default.
• W2890919276 cites W2093856275 @default.
• W2890919276 cites W2094618246 @default.
• W2890919276 cites W2096561615 @default.
• W2890919276 cites W2099478180 @default.
• W2890919276 cites W2101178259 @default.
• W2890919276 cites W2103328620 @default.
• W2890919276 cites W2103479702 @default.
• W2890919276 cites W2104664296 @default.
• W2890919276 cites W2107103928 @default.
• W2890919276 cites W2113113253 @default.
• W2890919276 cites W2114888924 @default.
• W2890919276 cites W2120155377 @default.
• W2890919276 cites W2120223157 @default.
• W2890919276 cites W2129599351 @default.
• W2890919276 cites W2136514333 @default.
• W2890919276 cites W2145120190 @default.
• W2890919276 cites W2158204588 @default.
• W2890919276 cites W2169142987 @default.
• W2890919276 cites W2176749909 @default.
• W2890919276 cites W2202510332 @default.
• W2890919276 cites W2213122689 @default.
• W2890919276 cites W2315569879 @default.
• W2890919276 cites W2377678051 @default.
• W2890919276 cites W2413582352 @default.
• W2890919276 cites W2417724905 @default.
• W2890919276 cites W2565727305 @default.
• W2890919276 cites W2616863796 @default.
• W2890919276 cites W2648952709 @default.
• W2890919276 cites W2770567298 @default.
• W2890919276 cites W2774064966 @default.
• W2890919276 cites W2778169119 @default.
• W2890919276 doi "https://doi.org/10.1016/j.eplepsyres.2018.09.007" @default.
• W2890919276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6226012" @default.
• W2890919276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261353" @default.

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