Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890922017> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2890922017 abstract "The use of latency reversing agents (LRAs) is currently a promising approach to eliminate latent reservoirs of HIV-1. However, this strategy has not been successful in vivo. It has been proposed that cellular post-transcriptional mechanisms are implicated in the underperformance of LRAs, but it is not clear whether proviral regulatory elements like viral non-coding RNAs (vncRNAs) are also implicated. In order to visualize the complexity of the HIV-1 gene expression, we used experimental data to construct a gene regulatory network (GRN) of latent proviruses in resting CD4+ T cells. We then analyzed the dynamics of this GRN using Boolean and continuous mathematical models. Our simulations predict that vncRNAs are able to counteract the activity of LRAs, which may explain the failure of these compounds to reactivate latent reservoirs of HIV-1. Moreover, our results also predict that using inhibitors of histone methyltransferases, such as chaetocin, together with releasers of the positive transcription elongation factor (P-TEFb), like JQ1, may increase proviral reactivation despite self-repressive effects of vncRNAs." @default.
- W2890922017 created "2018-09-27" @default.
- W2890922017 creator A5019909472 @default.
- W2890922017 creator A5032018922 @default.
- W2890922017 creator A5032397695 @default.
- W2890922017 creator A5034642171 @default.
- W2890922017 date "2018-01-01" @default.
- W2890922017 modified "2023-09-23" @default.
- W2890922017 title "Dynamics of the gene regulatory network of HIV-1 and the role of viral non-coding RNAs on latency reversion" @default.
- W2890922017 doi "https://doi.org/10.3389/fgene.2018.00334" @default.
- W2890922017 hasPublicationYear "2018" @default.
- W2890922017 type Work @default.
- W2890922017 sameAs 2890922017 @default.
- W2890922017 citedByCount "0" @default.
- W2890922017 crossrefType "journal-article" @default.
- W2890922017 hasAuthorship W2890922017A5019909472 @default.
- W2890922017 hasAuthorship W2890922017A5032018922 @default.
- W2890922017 hasAuthorship W2890922017A5032397695 @default.
- W2890922017 hasAuthorship W2890922017A5034642171 @default.
- W2890922017 hasConcept C104317684 @default.
- W2890922017 hasConcept C127716648 @default.
- W2890922017 hasConcept C140704245 @default.
- W2890922017 hasConcept C150194340 @default.
- W2890922017 hasConcept C2522874641 @default.
- W2890922017 hasConcept C2778852064 @default.
- W2890922017 hasConcept C41008148 @default.
- W2890922017 hasConcept C41091548 @default.
- W2890922017 hasConcept C54355233 @default.
- W2890922017 hasConcept C64927066 @default.
- W2890922017 hasConcept C67339327 @default.
- W2890922017 hasConcept C70721500 @default.
- W2890922017 hasConcept C70883133 @default.
- W2890922017 hasConcept C76155785 @default.
- W2890922017 hasConcept C82876162 @default.
- W2890922017 hasConcept C86803240 @default.
- W2890922017 hasConceptScore W2890922017C104317684 @default.
- W2890922017 hasConceptScore W2890922017C127716648 @default.
- W2890922017 hasConceptScore W2890922017C140704245 @default.
- W2890922017 hasConceptScore W2890922017C150194340 @default.
- W2890922017 hasConceptScore W2890922017C2522874641 @default.
- W2890922017 hasConceptScore W2890922017C2778852064 @default.
- W2890922017 hasConceptScore W2890922017C41008148 @default.
- W2890922017 hasConceptScore W2890922017C41091548 @default.
- W2890922017 hasConceptScore W2890922017C54355233 @default.
- W2890922017 hasConceptScore W2890922017C64927066 @default.
- W2890922017 hasConceptScore W2890922017C67339327 @default.
- W2890922017 hasConceptScore W2890922017C70721500 @default.
- W2890922017 hasConceptScore W2890922017C70883133 @default.
- W2890922017 hasConceptScore W2890922017C76155785 @default.
- W2890922017 hasConceptScore W2890922017C82876162 @default.
- W2890922017 hasConceptScore W2890922017C86803240 @default.
- W2890922017 hasLocation W28909220171 @default.
- W2890922017 hasOpenAccess W2890922017 @default.
- W2890922017 hasPrimaryLocation W28909220171 @default.
- W2890922017 hasRelatedWork W101927578 @default.
- W2890922017 hasRelatedWork W1417481847 @default.
- W2890922017 hasRelatedWork W171718782 @default.
- W2890922017 hasRelatedWork W1990990554 @default.
- W2890922017 hasRelatedWork W2018242562 @default.
- W2890922017 hasRelatedWork W2023492807 @default.
- W2890922017 hasRelatedWork W2065836335 @default.
- W2890922017 hasRelatedWork W2120488252 @default.
- W2890922017 hasRelatedWork W2135402414 @default.
- W2890922017 hasRelatedWork W2387737284 @default.
- W2890922017 hasRelatedWork W2529391095 @default.
- W2890922017 hasRelatedWork W2610771618 @default.
- W2890922017 hasRelatedWork W2744218338 @default.
- W2890922017 hasRelatedWork W2883999028 @default.
- W2890922017 hasRelatedWork W2893201463 @default.
- W2890922017 hasRelatedWork W2981136854 @default.
- W2890922017 hasRelatedWork W3014444433 @default.
- W2890922017 hasRelatedWork W3022613285 @default.
- W2890922017 hasRelatedWork W3025325754 @default.
- W2890922017 hasRelatedWork W2781023628 @default.
- W2890922017 hasVolume "9" @default.
- W2890922017 isParatext "false" @default.
- W2890922017 isRetracted "false" @default.
- W2890922017 magId "2890922017" @default.
- W2890922017 workType "article" @default.