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• W2890924006 abstract "Besides understanding the effectiveness of N-acetylcysteine (NAC) for the treatment of disease and its effect on physiological systems, other considerations of NAC are important, including the pharmacology, formulations, and adverse effects of NAC. This chapter will review these important aspects of NAC. Few published trials have examined the pharmacokinetics of NAC. Maximum plasma concentration increases with oral NAC doses (up to 1200 mg has been studied), particularly with sustained-release formulations. Oral and intravenous NAC seems to have similar half-lives (around 6 h). The pharmacokinetics of NAC is altered by chronic liver and renal disease as well as exercise. Clearance is altered in the neonatal period and with dialysis. NAC does not appear to alter the concentration of several common antibiotics, including amoxicillin, cefadroxil, cefpodoxime, doxycycline, and erythromycin. There are many nonprescription forms of NAC that are not regulated, particularly in the United States, which can easily oxidize in its dimeric form (“di-NAC”) which can result in opposite physiological effects. There are several formulations that follow Good Manufacturing Practice standards that are believed to be more stable." @default.
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• W2890924006 date "2018-09-21" @default.
• W2890924006 modified "2023-10-16" @default.
• W2890924006 title "Pharmacology, Formulations, and Adverse Effects" @default.
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• W2890924006 doi "https://doi.org/10.1007/978-981-10-5311-5_21" @default.
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