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- W2890924925 abstract "e17011 Background: Standard treatment for stage IA2 carcinoma of the cervix consists of modified radical hysterectomy or pelvic radiation. The objective of this study was to compare outcomes of less radical surgery (LRS, defined as conization, trachelectomy or simple hysterectomy) with more radical surgery (MRS, defined as modified radical or radical hysterectomy) in young women with stage IA2 cervical cancer. Methods: Using the Surveillance, Epidemiology and End Results (SEER) database, we identified women younger than age 45 diagnosed with FIGO stage IA2 squamous cell, adenocarcinoma, or adenosquamous carcinoma of the cervix between 1998 and 2012. Associated factors and disease-specific survival (DSS) of LRS vs MRS were analyzed. Appropriate univariate and multivariate statistical testing was performed. Results: Of the 1343 women who met inclusion criteria, 872 underwent LRS (conization 24%, trachelectomy 4%, simple hysterectomy 72%) and 471 underwent MRS (modified radical hysterectomy 19%, radical hysterectomy 26%, modified radical/radical hysterectomy 55%). For LRS vs MRS, 80% vs 65% of women had disease of squamous cell histology (p < .001), 30% vs 94% underwent regional lymphadenectomy (p < .001), and 2% vs 4% had positive lymph nodes (p = .04). Median age, race, marital status, and SEER region did not differ significantly between the two groups. Those with adenocarcinoma, adenosquamous carcinoma, or grade 3 disease were more likely to undergo MRS than LRS (OR 1.74, 95% CI 1.29-2.34; OR 2.39, 95% CI 1.31-4.37; OR 1.84, 95% CI 1.15-2.92). With a median follow-up of 110 months (range, 0-179), 10-year DSS for LRS vs MRS was 98.3% vs 98.2% (SE ± 0.5, 0.7; p = .87). Lymph node positivity was the only factor independently associated with DSS (HR 11.63, 95% CI 2.08-65.23). When stratified by histologic subtype, DSS for LRS vs MRS was as follows: squamous cell, 98.5% vs 97.6% (SE ± 0.5, 0.1; p = .69); adenocarcinoma, 97.7% vs 100% (SE ± 1.7, 0.0; p = .20); and adenosquamous carcinoma, 93.8% vs 96.3% (SE ± 6.1, 3.6; p = .87). Conclusions: In young women with stage IA2 cervical cancer, treatment with conization, trachelectomy, or simple hysterectomy does not appear to compromise DSS." @default.
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- W2890924925 date "2016-05-20" @default.
- W2890924925 modified "2023-10-16" @default.
- W2890924925 title "Stage IA2 cervical cancer: Long-term outcomes with less radical as opposed to more radical surgical management." @default.
- W2890924925 doi "https://doi.org/10.1200/jco.2016.34.15_suppl.e17011" @default.
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