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• W2890927910 abstract "Significance Delivery of most drug carriers to the kidney is limited because of their uptake by the reticuloendothelial system in the liver and spleen. We have developed l -serine (Ser)–modified polyamidoamine dendrimer (PAMAM) as a potent renal targeting drug carrier for the treatment of kidney diseases. Pharmacokinetic and single-photon emission computed tomography/computed tomography studies indicated that Ser modification results in efficient kidney targeting of PAMAM. Ser-PAMAM accumulated predominantly in proximal tubules, a pattern associated with the pathogenesis of renal cell carcinoma and chronic renal failure. Efficient renal distribution and pharmacologic effect of captopril was observed after i.v. injection of the Ser-PAMAM-captopril conjugate. Thus, our results demonstrate successful kidney targeting of a drug carrier via Ser modification." @default.
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• W2890927910 date "2018-09-24" @default.
• W2890927910 modified "2023-10-01" @default.
• W2890927910 title "<scp>l</scp> -Serine–modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier" @default.
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• W2890927910 doi "https://doi.org/10.1073/pnas.1808168115" @default.
• W2890927910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187148" @default.
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