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• W2890928025 abstract "Estrogen affects cell growth and IGF-1 receptor expression in renal cell carcinoma Lijiang Sun,* Zhemin Gao,* Lei Luo, Hailin Tan, Guiming Zhang Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China *These authors contributed equally to this work Purpose: Both obesity and gender are important etiological factors in renal cell carcinoma (RCC) development, suggesting a pivotal role of sex hormone signaling pathway and insulin-like growth factor (IGF) family in RCC carcinogenesis. Here, we aimed to investigate the effect of estrogen on RCC growth and the possible interaction between estrogen/estrogen receptor (ER) signaling pathway and the IGF axis. Methods: ER-α and ER-β were detected in four human RCC cell lines. Cells were treated with 17β-estradiol (E2), and cell proliferation was determined using the cell counting kit-8 assay. Using siRNA, ER-β was downregulated in RCC cells and the effect of E2 on cell growth and IGF-1 receptor (IGF-1R) expression was examined. Results: E2 inhibited 786-O cell but not A498 cell growth significantly. After the downregulation of ER-β, E2 showed no obvious inhibitory role in 786-O cells. E2 stimulation increased the expression of IGF-1R in 786-O cells. Downregulation of ER-β, as well as fulvestrant, attenuated the stimulatory effect of E2 on IGF-1R expression. Conclusion: Our results revealed that estrogen induced RCC growth inhibition via an ER-β-dependent pathway. Estrogen also upregulated the expression of IGF-1R, suggesting a link between estrogen/ER and IGF axis. Keywords: renal cell carcinoma, estrogen, insulin-like growth factor-1 receptor" @default.
• W2890928025 created "2018-09-27" @default.
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• W2890928025 date "2018-09-01" @default.
• W2890928025 modified "2023-10-16" @default.
• W2890928025 title "Estrogen affects cell growth and IGF-1 receptor expression in renal cell carcinoma" @default.
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• W2890928025 doi "https://doi.org/10.2147/ott.s172149" @default.
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