Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890931914> ?p ?o ?g. }
- W2890931914 abstract "Abstract Significant recent evidence suggests that metabolism is intricately linked to the regulation and dysfunction of complex cellular and physiological responses ranging from altered metabolic programs in cancers and aging to circadian rhythms and molecular clocks. While the metabolic pathways and their fundamental control mechanisms are well established, the precise cellular mechanisms underpinning, for example, enzymatic pathway control, substrate preferences or metabolic rates, remain far less certain. Comprehensive, continuous metabolic studies on model organisms, such as the fruit fly Drosophila melanogaster , may provide a critical tool for deciphering these complex physiological responses. Here, we describe the development of a high-resolution calorimeter, which combines sensitive thermometry with optical imaging to concurrently perform measurements of the metabolic rate of ten individual flies, in real-time, with ~100 nW resolution. Using this calorimeter we have measured the mass-specific metabolic rates of flies of different genotypes, ages, and flies fed with different diets. This powerful new approach enables systematic studies of the metabolic regulation related to cellular and physiological function and disease mechanisms." @default.
- W2890931914 created "2018-09-27" @default.
- W2890931914 creator A5000723312 @default.
- W2890931914 creator A5018393057 @default.
- W2890931914 creator A5018785890 @default.
- W2890931914 creator A5076746488 @default.
- W2890931914 creator A5083734817 @default.
- W2890931914 creator A5090599172 @default.
- W2890931914 creator A5091460484 @default.
- W2890931914 date "2018-09-27" @default.
- W2890931914 modified "2023-10-18" @default.
- W2890931914 title "Parallelized, real-time, metabolic-rate measurements from individual Drosophila" @default.
- W2890931914 cites W1550170046 @default.
- W2890931914 cites W1933788686 @default.
- W2890931914 cites W1963878813 @default.
- W2890931914 cites W1972930184 @default.
- W2890931914 cites W1975344770 @default.
- W2890931914 cites W1976193732 @default.
- W2890931914 cites W1982074552 @default.
- W2890931914 cites W1983271741 @default.
- W2890931914 cites W1996914636 @default.
- W2890931914 cites W2000907138 @default.
- W2890931914 cites W2004923406 @default.
- W2890931914 cites W2007299852 @default.
- W2890931914 cites W2012649861 @default.
- W2890931914 cites W2019865464 @default.
- W2890931914 cites W2028789012 @default.
- W2890931914 cites W2034810986 @default.
- W2890931914 cites W2035010201 @default.
- W2890931914 cites W2039356857 @default.
- W2890931914 cites W2050098451 @default.
- W2890931914 cites W2053493267 @default.
- W2890931914 cites W2063212818 @default.
- W2890931914 cites W2066455826 @default.
- W2890931914 cites W2067395327 @default.
- W2890931914 cites W2074319561 @default.
- W2890931914 cites W2082966250 @default.
- W2890931914 cites W2088192500 @default.
- W2890931914 cites W2090215290 @default.
- W2890931914 cites W2093419981 @default.
- W2890931914 cites W2098343475 @default.
- W2890931914 cites W2100542429 @default.
- W2890931914 cites W2101600063 @default.
- W2890931914 cites W2105765501 @default.
- W2890931914 cites W2112199856 @default.
- W2890931914 cites W2112299930 @default.
- W2890931914 cites W2118836965 @default.
- W2890931914 cites W2119825866 @default.
- W2890931914 cites W2129849137 @default.
- W2890931914 cites W2137330513 @default.
- W2890931914 cites W2141478497 @default.
- W2890931914 cites W2143730031 @default.
- W2890931914 cites W2157481078 @default.
- W2890931914 cites W2162790428 @default.
- W2890931914 cites W2169735054 @default.
- W2890931914 cites W2234115940 @default.
- W2890931914 cites W2284388501 @default.
- W2890931914 cites W2289876562 @default.
- W2890931914 cites W2315512556 @default.
- W2890931914 cites W2507936136 @default.
- W2890931914 cites W2557270017 @default.
- W2890931914 cites W2586138158 @default.
- W2890931914 cites W4243239840 @default.
- W2890931914 cites W604196653 @default.
- W2890931914 doi "https://doi.org/10.1038/s41598-018-32744-0" @default.
- W2890931914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160429" @default.
- W2890931914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262912" @default.
- W2890931914 hasPublicationYear "2018" @default.
- W2890931914 type Work @default.
- W2890931914 sameAs 2890931914 @default.
- W2890931914 citedByCount "14" @default.
- W2890931914 countsByYear W28909319142019 @default.
- W2890931914 countsByYear W28909319142020 @default.
- W2890931914 countsByYear W28909319142021 @default.
- W2890931914 countsByYear W28909319142022 @default.
- W2890931914 countsByYear W28909319142023 @default.
- W2890931914 crossrefType "journal-article" @default.
- W2890931914 hasAuthorship W2890931914A5000723312 @default.
- W2890931914 hasAuthorship W2890931914A5018393057 @default.
- W2890931914 hasAuthorship W2890931914A5018785890 @default.
- W2890931914 hasAuthorship W2890931914A5076746488 @default.
- W2890931914 hasAuthorship W2890931914A5083734817 @default.
- W2890931914 hasAuthorship W2890931914A5090599172 @default.
- W2890931914 hasAuthorship W2890931914A5091460484 @default.
- W2890931914 hasBestOaLocation W28909319141 @default.
- W2890931914 hasConcept C101810790 @default.
- W2890931914 hasConcept C104317684 @default.
- W2890931914 hasConcept C134018914 @default.
- W2890931914 hasConcept C150903083 @default.
- W2890931914 hasConcept C152662350 @default.
- W2890931914 hasConcept C169760540 @default.
- W2890931914 hasConcept C192989942 @default.
- W2890931914 hasConcept C2776041557 @default.
- W2890931914 hasConcept C2779306644 @default.
- W2890931914 hasConcept C2780104201 @default.
- W2890931914 hasConcept C2991986269 @default.
- W2890931914 hasConcept C2992768293 @default.
- W2890931914 hasConcept C2993927895 @default.
- W2890931914 hasConcept C42407357 @default.
- W2890931914 hasConcept C54355233 @default.