Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890932215> ?p ?o ?g. }
- W2890932215 endingPage "705" @default.
- W2890932215 startingPage "684" @default.
- W2890932215 abstract "Escherichia coli Dihydrofolate reductase is an important enzyme that is essential for the survival of the Gram-negative microorganism. Inhibitors designed against this enzyme have demonstrated application as antibiotics. However, either because of poor bioavailability of the small-molecules resulting from their inability to cross the double membrane in Gram-negative bacteria or because the microorganism develops resistance to the antibiotics by mutating the DHFR target, discovery of new antibiotics against the enzyme is mandatory to overcome drug-resistance. This review summarizes the field of DHFR inhibition with special focus on recent efforts to effectively interface computational and experimental efforts to discover novel classes of inhibitors that target allosteric and active-sites in drug-resistant variants of EcDHFR." @default.
- W2890932215 created "2018-09-27" @default.
- W2890932215 creator A5010808261 @default.
- W2890932215 creator A5014930819 @default.
- W2890932215 creator A5022257357 @default.
- W2890932215 creator A5057942364 @default.
- W2890932215 creator A5082120044 @default.
- W2890932215 date "2018-09-07" @default.
- W2890932215 modified "2023-09-29" @default.
- W2890932215 title "Chemical space of<i>Escherichia coli</i>dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs" @default.
- W2890932215 cites W1254634972 @default.
- W2890932215 cites W1491063906 @default.
- W2890932215 cites W1515673187 @default.
- W2890932215 cites W1531916394 @default.
- W2890932215 cites W1562157741 @default.
- W2890932215 cites W1564028741 @default.
- W2890932215 cites W1573080626 @default.
- W2890932215 cites W1573233356 @default.
- W2890932215 cites W1579095159 @default.
- W2890932215 cites W1587498640 @default.
- W2890932215 cites W1818833536 @default.
- W2890932215 cites W1961044295 @default.
- W2890932215 cites W1965172214 @default.
- W2890932215 cites W1966118948 @default.
- W2890932215 cites W1966470598 @default.
- W2890932215 cites W1968620174 @default.
- W2890932215 cites W1970651561 @default.
- W2890932215 cites W1971062326 @default.
- W2890932215 cites W1973974137 @default.
- W2890932215 cites W1976749451 @default.
- W2890932215 cites W1976975528 @default.
- W2890932215 cites W1979040389 @default.
- W2890932215 cites W1980524534 @default.
- W2890932215 cites W1981433258 @default.
- W2890932215 cites W1981683411 @default.
- W2890932215 cites W1982240222 @default.
- W2890932215 cites W1982798915 @default.
- W2890932215 cites W1983194490 @default.
- W2890932215 cites W1984219340 @default.
- W2890932215 cites W1988564488 @default.
- W2890932215 cites W1990451437 @default.
- W2890932215 cites W1992515664 @default.
- W2890932215 cites W1992683366 @default.
- W2890932215 cites W1994037959 @default.
- W2890932215 cites W1994246907 @default.
- W2890932215 cites W1995288235 @default.
- W2890932215 cites W1998912666 @default.
- W2890932215 cites W2006774276 @default.
- W2890932215 cites W2007537494 @default.
- W2890932215 cites W2011257775 @default.
- W2890932215 cites W2012977051 @default.
- W2890932215 cites W2013296244 @default.
- W2890932215 cites W2015461838 @default.
- W2890932215 cites W2020327537 @default.
- W2890932215 cites W2022516190 @default.
- W2890932215 cites W2022644236 @default.
- W2890932215 cites W2028440694 @default.
- W2890932215 cites W2030316086 @default.
- W2890932215 cites W2031390939 @default.
- W2890932215 cites W2040599251 @default.
- W2890932215 cites W2041205020 @default.
- W2890932215 cites W2042001883 @default.
- W2890932215 cites W2042774422 @default.
- W2890932215 cites W2045318774 @default.
- W2890932215 cites W2046813714 @default.
- W2890932215 cites W2053012672 @default.
- W2890932215 cites W2053578439 @default.
- W2890932215 cites W2058418533 @default.
- W2890932215 cites W2060153789 @default.
- W2890932215 cites W2061587487 @default.
- W2890932215 cites W2063237193 @default.
- W2890932215 cites W2063774385 @default.
- W2890932215 cites W2064494898 @default.
- W2890932215 cites W2067789330 @default.
- W2890932215 cites W2068372433 @default.
- W2890932215 cites W2070110265 @default.
- W2890932215 cites W2070662628 @default.
- W2890932215 cites W2073350684 @default.
- W2890932215 cites W2074364042 @default.
- W2890932215 cites W2081032008 @default.
- W2890932215 cites W2081729133 @default.
- W2890932215 cites W2083144176 @default.
- W2890932215 cites W2083361186 @default.
- W2890932215 cites W2083467467 @default.
- W2890932215 cites W2084501039 @default.
- W2890932215 cites W2085315829 @default.
- W2890932215 cites W2085429539 @default.
- W2890932215 cites W2087824460 @default.
- W2890932215 cites W2088603940 @default.
- W2890932215 cites W2089381008 @default.
- W2890932215 cites W2096541451 @default.
- W2890932215 cites W2098530568 @default.
- W2890932215 cites W2099388354 @default.
- W2890932215 cites W2104192693 @default.
- W2890932215 cites W2104396548 @default.
- W2890932215 cites W2111143975 @default.
- W2890932215 cites W2116777154 @default.
- W2890932215 cites W2121790192 @default.