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- W2890933287 endingPage "824" @default.
- W2890933287 startingPage "803" @default.
- W2890933287 abstract "Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance." @default.
- W2890933287 created "2018-09-27" @default.
- W2890933287 creator A5030912064 @default.
- W2890933287 creator A5075296559 @default.
- W2890933287 creator A5078054009 @default.
- W2890933287 creator A5082405402 @default.
- W2890933287 creator A5091865962 @default.
- W2890933287 date "2018-09-14" @default.
- W2890933287 modified "2023-10-18" @default.
- W2890933287 title "Autophagy in Cardiovascular Aging" @default.
- W2890933287 cites W1497266024 @default.
- W2890933287 cites W1506510867 @default.
- W2890933287 cites W1565979608 @default.
- W2890933287 cites W1567840615 @default.
- W2890933287 cites W1575189699 @default.
- W2890933287 cites W1578616085 @default.
- W2890933287 cites W1581119831 @default.
- W2890933287 cites W164205712 @default.
- W2890933287 cites W1643149493 @default.
- W2890933287 cites W1646601758 @default.
- W2890933287 cites W1751574485 @default.
- W2890933287 cites W1769035943 @default.
- W2890933287 cites W1783515128 @default.
- W2890933287 cites W1823641798 @default.
- W2890933287 cites W1851431531 @default.
- W2890933287 cites W1857010474 @default.
- W2890933287 cites W1880366974 @default.
- W2890933287 cites W1887169756 @default.
- W2890933287 cites W1908925080 @default.
- W2890933287 cites W1924955228 @default.
- W2890933287 cites W1936102533 @default.
- W2890933287 cites W1947637767 @default.
- W2890933287 cites W1963521777 @default.
- W2890933287 cites W1964850312 @default.
- W2890933287 cites W1965305002 @default.
- W2890933287 cites W1965575508 @default.
- W2890933287 cites W1969408132 @default.
- W2890933287 cites W1970637701 @default.
- W2890933287 cites W1972601497 @default.
- W2890933287 cites W1974724441 @default.
- W2890933287 cites W1975439065 @default.
- W2890933287 cites W1975964850 @default.
- W2890933287 cites W1978172515 @default.
- W2890933287 cites W1978548065 @default.
- W2890933287 cites W1979665155 @default.
- W2890933287 cites W1980084094 @default.
- W2890933287 cites W1980192302 @default.
- W2890933287 cites W1980955874 @default.
- W2890933287 cites W1982664954 @default.
- W2890933287 cites W1984608691 @default.
- W2890933287 cites W1987034100 @default.
- W2890933287 cites W1988044873 @default.
- W2890933287 cites W1988236300 @default.
- W2890933287 cites W1988445456 @default.
- W2890933287 cites W1988743087 @default.
- W2890933287 cites W1990191024 @default.
- W2890933287 cites W1991692801 @default.
- W2890933287 cites W1992659717 @default.
- W2890933287 cites W1995175684 @default.
- W2890933287 cites W1995487745 @default.
- W2890933287 cites W1998880096 @default.
- W2890933287 cites W2001199231 @default.
- W2890933287 cites W2003417689 @default.
- W2890933287 cites W2006840724 @default.
- W2890933287 cites W2007846859 @default.
- W2890933287 cites W2010342922 @default.
- W2890933287 cites W2010583480 @default.
- W2890933287 cites W2012937190 @default.
- W2890933287 cites W2014843536 @default.
- W2890933287 cites W2016518406 @default.
- W2890933287 cites W2016826534 @default.
- W2890933287 cites W2017018900 @default.
- W2890933287 cites W2019041167 @default.
- W2890933287 cites W2020145471 @default.
- W2890933287 cites W2021410503 @default.
- W2890933287 cites W2021632384 @default.
- W2890933287 cites W2024782183 @default.
- W2890933287 cites W2025133084 @default.
- W2890933287 cites W2026722078 @default.
- W2890933287 cites W2028178274 @default.
- W2890933287 cites W2028415167 @default.
- W2890933287 cites W2028452724 @default.
- W2890933287 cites W2030548258 @default.
- W2890933287 cites W2031373028 @default.
- W2890933287 cites W2033656398 @default.
- W2890933287 cites W2036781838 @default.
- W2890933287 cites W2040918084 @default.
- W2890933287 cites W2041719399 @default.
- W2890933287 cites W2045611938 @default.
- W2890933287 cites W2048282904 @default.
- W2890933287 cites W2048376025 @default.
- W2890933287 cites W2048963838 @default.
- W2890933287 cites W2049305779 @default.
- W2890933287 cites W2049685142 @default.
- W2890933287 cites W2050532980 @default.
- W2890933287 cites W2052764032 @default.
- W2890933287 cites W2054670968 @default.
- W2890933287 cites W2054879507 @default.