Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890938493> ?p ?o ?g. }
- W2890938493 abstract "Glyoxalase-1 (GLO1) is a ubiquitously expressed cytosolic protein which plays a role in the natural maintenance of cellular health and is abundantly expressed in human skeletal muscle. A consequence of reduced GLO1 protein expression is cellular dicarbonyl stress, which is elevated in obesity, insulin resistance and type 2 diabetes (T2DM). Both in vitro and pre-clinical models suggest dicarbonyl stress per se induces insulin resistance and is prevented by GLO1 overexpression, implicating a potential role for GLO1 therapy in insulin resistance and type 2 diabetes (T2DM). Recent work has identified the therapeutic potential of novel natural agents as a GLO1 inducer, which resulted in improved whole-body metabolism in obese adults. Given skeletal muscle is a major contributor to whole-body glucose, lipid, and protein metabolism, such GLO1 inducers may act, in part, through mechanisms in skeletal muscle. Currently, investigations examining the specificity of dicarbonyl stress and GLO1 biology in human skeletal muscle are lacking. Recent work from our lab indicates that dysregulation of GLO1 in skeletal muscle may underlie human insulin resistance and that exercise training may impart therapeutic benefits. This minireview will summarize the existing human literature examining skeletal muscle GLO1 and highlight the emerging therapeutic concepts for GLO1 gain-of-function in conditions such as insulin resistance and cardiometabolic disease." @default.
- W2890938493 created "2018-09-27" @default.
- W2890938493 creator A5014871972 @default.
- W2890938493 creator A5016698163 @default.
- W2890938493 date "2018-09-10" @default.
- W2890938493 modified "2023-10-18" @default.
- W2890938493 title "Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes" @default.
- W2890938493 cites W1502047387 @default.
- W2890938493 cites W1561695121 @default.
- W2890938493 cites W1839260472 @default.
- W2890938493 cites W1911388308 @default.
- W2890938493 cites W1966356997 @default.
- W2890938493 cites W1967855410 @default.
- W2890938493 cites W1968141749 @default.
- W2890938493 cites W1969469920 @default.
- W2890938493 cites W1970103021 @default.
- W2890938493 cites W1973303689 @default.
- W2890938493 cites W1974498385 @default.
- W2890938493 cites W1974499645 @default.
- W2890938493 cites W1981136207 @default.
- W2890938493 cites W1981446038 @default.
- W2890938493 cites W1982498947 @default.
- W2890938493 cites W1987355536 @default.
- W2890938493 cites W1989912928 @default.
- W2890938493 cites W1990675333 @default.
- W2890938493 cites W1992547263 @default.
- W2890938493 cites W1994051814 @default.
- W2890938493 cites W1996975797 @default.
- W2890938493 cites W1997604729 @default.
- W2890938493 cites W1999055051 @default.
- W2890938493 cites W2006088447 @default.
- W2890938493 cites W2010699144 @default.
- W2890938493 cites W2011605334 @default.
- W2890938493 cites W2016795949 @default.
- W2890938493 cites W2017997324 @default.
- W2890938493 cites W2019226618 @default.
- W2890938493 cites W2019853855 @default.
- W2890938493 cites W2022173379 @default.
- W2890938493 cites W2025787719 @default.
- W2890938493 cites W2026131755 @default.
- W2890938493 cites W2032055976 @default.
- W2890938493 cites W2033125833 @default.
- W2890938493 cites W2037251613 @default.
- W2890938493 cites W2041265416 @default.
- W2890938493 cites W2044188743 @default.
- W2890938493 cites W2044465082 @default.
- W2890938493 cites W2045431945 @default.
- W2890938493 cites W2048565142 @default.
- W2890938493 cites W2048594557 @default.
- W2890938493 cites W2059681268 @default.
- W2890938493 cites W2061315417 @default.
- W2890938493 cites W2062870716 @default.
- W2890938493 cites W2064787733 @default.
- W2890938493 cites W2067829426 @default.
- W2890938493 cites W2070058893 @default.
- W2890938493 cites W2072878932 @default.
- W2890938493 cites W2074254278 @default.
- W2890938493 cites W2090495023 @default.
- W2890938493 cites W2094026727 @default.
- W2890938493 cites W2102453677 @default.
- W2890938493 cites W2105052786 @default.
- W2890938493 cites W2105912552 @default.
- W2890938493 cites W2109228802 @default.
- W2890938493 cites W2109728760 @default.
- W2890938493 cites W2110774866 @default.
- W2890938493 cites W2112921272 @default.
- W2890938493 cites W2115320557 @default.
- W2890938493 cites W2116000137 @default.
- W2890938493 cites W2121598176 @default.
- W2890938493 cites W2124056915 @default.
- W2890938493 cites W2126044710 @default.
- W2890938493 cites W2126624644 @default.
- W2890938493 cites W2126972322 @default.
- W2890938493 cites W2127899368 @default.
- W2890938493 cites W2132399664 @default.
- W2890938493 cites W2134445381 @default.
- W2890938493 cites W2135027079 @default.
- W2890938493 cites W2136896338 @default.
- W2890938493 cites W2141255278 @default.
- W2890938493 cites W2146507019 @default.
- W2890938493 cites W2149079498 @default.
- W2890938493 cites W2152956628 @default.
- W2890938493 cites W2155962991 @default.
- W2890938493 cites W2157061952 @default.
- W2890938493 cites W2158394935 @default.
- W2890938493 cites W2160330411 @default.
- W2890938493 cites W2160424947 @default.
- W2890938493 cites W2164135579 @default.
- W2890938493 cites W2164714249 @default.
- W2890938493 cites W2165648599 @default.
- W2890938493 cites W2167061914 @default.
- W2890938493 cites W2169401893 @default.
- W2890938493 cites W2170721365 @default.
- W2890938493 cites W2171349277 @default.
- W2890938493 cites W2179653083 @default.
- W2890938493 cites W2202120377 @default.
- W2890938493 cites W2333847632 @default.
- W2890938493 cites W2336682594 @default.
- W2890938493 cites W2391680777 @default.
- W2890938493 cites W2401030213 @default.