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- W2890938970 abstract "An unprecedented reaction of thiourea derivatives with 6β-bromoandrostenedione has been discovered for the formation of aminothiazolo-androstenones via a simple, safer, cascade protocol that enables the syntheses of novel molecules by using readily available reagents. The reaction mechanism of product formation has been rationalized by density functional theory calculations. This benign methodology accentuates a domino protocol deploying a renewable solvent, ethanol, while generating novel compounds that display potent growth inhibitory effects in in vitro studies for several cancer cell lines at submicromolar concentrations." @default.
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- W2890938970 date "2018-09-11" @default.
- W2890938970 modified "2023-10-15" @default.
- W2890938970 title "Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents" @default.
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- W2890938970 doi "https://doi.org/10.1021/acs.orglett.8b02587" @default.
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