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- W2890939633 abstract "The proliferation of T cells in peripheral lymphoid tissues requires T cell receptor (TCR)-mediated cell cycle entry. However, the underlying mechanism regulating cell cycle progression in mature T cells is incompletely understood. Here, we have identified an E3 ubiquitin ligase, CRL4DCAF2, as a critical mediator controlling M phase exit in activated T cells. DCAF2 expression is induced upon TCR stimulation and its deficiency attenuates T cell expansion. Additionally, DCAF2 T cell-specific knockout mice display impaired peripheral T cell maintenance and reduced severity of various autoimmune diseases. Continuous H4K20me1 modification caused by DCAF2 deficiency inhibits the induction of Aurkb expression, which regulates 26S proteasome activity during G2/M phase. CRL4DCAF2 deficiency causes M phase arrest through proteasome-dependent mechanisms in peripheral T cells. Our findings establish DCAF2 as a novel target for T cell-mediated autoimmunity or inflammatory diseases." @default.
- W2890939633 created "2018-09-27" @default.
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- W2890939633 date "2019-01-01" @default.
- W2890939633 modified "2023-10-17" @default.
- W2890939633 title "CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity" @default.
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- W2890939633 doi "https://doi.org/10.1016/j.jaut.2018.08.006" @default.
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