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- W2890942431 abstract "Abstract Herein, two kinds of ssDNA-GNPs (termed as PolyG 1 -GNPs and PolyG 2 -GNPs, respectively) were synthesized by modification of two different G-rich single-strand oligonucleotides (PolyG 1 and PolyG 2 ) onto 13-nm citrate-protected gold nanoparticles (GNPs) surface through formation of the sulfur-gold covalent bond, respectively. The as-prepared PolyG 1 -GNPs and PolyG 2 -GNPs had reasonable colloidal stability in complex dispersing matrixes. The effect of ssDNA sequence on the interaction between ssDNA-GNPs and cells was systematically investigated by UV-visible absorption spectroscopy, cellular transmission electronic microscopy and inductively coupled plasma-mass spectrometry. The experimental results showed that both of the as-prepared PolyG 1 -GNPs and PolyG 2 -GNPs had low cytotoxicity and exhibited energy related endocytosis. In addition, the cellular internalization amount and dispersibility of ssDNA-GNPs were strongly affected by the sequences of immobilized ssDNAs. PolyG 2 with G-quadruplex (G4) secondary structure could significantly increase the cellular internalization amount and intracellular stability of PolyG 2 -GNPs." @default.
- W2890942431 created "2018-09-27" @default.
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- W2890942431 date "2018-09-01" @default.
- W2890942431 modified "2023-09-24" @default.
- W2890942431 title "Study on Interaction of G-rich Oligonucleotides Modified Gold Nanoparticles with Cells" @default.
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- W2890942431 doi "https://doi.org/10.1016/s1872-2040(18)61109-0" @default.
- W2890942431 hasPublicationYear "2018" @default.
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