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- W2890944761 abstract "Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson’s disease." @default.
- W2890944761 created "2018-09-27" @default.
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- W2890944761 date "2018-09-05" @default.
- W2890944761 modified "2023-10-17" @default.
- W2890944761 title "Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease" @default.
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- W2890944761 doi "https://doi.org/10.1021/acschemneuro.8b00288" @default.
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