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- W2890946688 abstract "Use of tumor-targeted fluorescence dyes to help surgeons identify otherwise undetected tumor nodules, decrease the incidence of cancer-positive margins, and facilitate localization of malignant lymph nodes has demonstrated considerable promise for improving cancer debulking surgery. Unfortunately, the repertoire of available tumor-targeted fluorescent dyes does not permit identification of all cancer types, raising the need to develop additional tumor-specific fluorescent dyes to ensure localization of all malignant lesions during cancer surgeries. By comparing the mRNA levels of the hypoxia-induced plasma membrane protein carbonic anhydrase IX (CA IX) in 13 major human cancers with the same mRNA levels in corresponding normal tissues, we document that CA IX constitutes a nearly universal marker for the design of tumor-targeted fluorescent dyes. Motivated by this expression profile, we synthesize two new CA IX-targeted near-infrared (NIR) fluorescent imaging agents and characterize their physical and biological properties both in vitro and in vivo. We report that conjugation of either acetazolamide or 6-aminosaccharin (i.e., two CA-IX-specific ligands) to the NIR fluorescent dye, S0456, via an extended phenolic spacer creates a brightly fluorescent dye that binds CA IX with high affinity and allows rapid visualization of hypoxic regions of solid tumors at depths >1 cm beneath a tissue surface. Taken together, these data suggest that a CA IX-targeted NIR dye can constitute a useful addition to a cocktail of tumor-targeted NIR dyes designed to image all human cancers." @default.
- W2890946688 created "2018-09-27" @default.
- W2890946688 creator A5046589115 @default.
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- W2890946688 creator A5085542989 @default.
- W2890946688 creator A5085586317 @default.
- W2890946688 creator A5089609044 @default.
- W2890946688 date "2018-09-06" @default.
- W2890946688 modified "2023-10-11" @default.
- W2890946688 title "Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors" @default.
- W2890946688 cites W1572736799 @default.
- W2890946688 cites W1793282116 @default.
- W2890946688 cites W1886557506 @default.
- W2890946688 cites W1918904712 @default.
- W2890946688 cites W1952033964 @default.
- W2890946688 cites W1964128680 @default.
- W2890946688 cites W1964909390 @default.
- W2890946688 cites W1965807362 @default.
- W2890946688 cites W1980640822 @default.
- W2890946688 cites W1982548635 @default.
- W2890946688 cites W1985588649 @default.
- W2890946688 cites W1985921616 @default.
- W2890946688 cites W1988858603 @default.
- W2890946688 cites W1991945497 @default.
- W2890946688 cites W1993147241 @default.
- W2890946688 cites W2002767447 @default.
- W2890946688 cites W2009345208 @default.
- W2890946688 cites W2009423060 @default.
- W2890946688 cites W2010469141 @default.
- W2890946688 cites W2014367004 @default.
- W2890946688 cites W2023114941 @default.
- W2890946688 cites W2024516085 @default.
- W2890946688 cites W2027559073 @default.
- W2890946688 cites W2028932185 @default.
- W2890946688 cites W2031360791 @default.
- W2890946688 cites W2032947646 @default.
- W2890946688 cites W2037715584 @default.
- W2890946688 cites W2040984589 @default.
- W2890946688 cites W2042488807 @default.
- W2890946688 cites W2046257292 @default.
- W2890946688 cites W2047033241 @default.
- W2890946688 cites W2047178318 @default.
- W2890946688 cites W2048237713 @default.
- W2890946688 cites W2049490668 @default.
- W2890946688 cites W2049815086 @default.
- W2890946688 cites W2052203042 @default.
- W2890946688 cites W2055948888 @default.
- W2890946688 cites W2059172412 @default.
- W2890946688 cites W2060459188 @default.
- W2890946688 cites W2063756151 @default.
- W2890946688 cites W2064442490 @default.
- W2890946688 cites W2079145821 @default.
- W2890946688 cites W2080577190 @default.
- W2890946688 cites W2082686355 @default.
- W2890946688 cites W2093146854 @default.
- W2890946688 cites W2098131572 @default.
- W2890946688 cites W2099521317 @default.
- W2890946688 cites W2101939482 @default.
- W2890946688 cites W2102377211 @default.
- W2890946688 cites W2105689679 @default.
- W2890946688 cites W2108664872 @default.
- W2890946688 cites W2108695923 @default.
- W2890946688 cites W2112579958 @default.
- W2890946688 cites W2118956445 @default.
- W2890946688 cites W2122148781 @default.
- W2890946688 cites W2126781383 @default.
- W2890946688 cites W2129356845 @default.
- W2890946688 cites W2137870051 @default.
- W2890946688 cites W2140483208 @default.
- W2890946688 cites W2155860718 @default.
- W2890946688 cites W2161672422 @default.
- W2890946688 cites W2163764479 @default.
- W2890946688 cites W2164969543 @default.
- W2890946688 cites W2204695292 @default.
- W2890946688 cites W2210860830 @default.
- W2890946688 cites W2259689259 @default.
- W2890946688 cites W2313063363 @default.
- W2890946688 cites W2314505911 @default.
- W2890946688 cites W2326308392 @default.
- W2890946688 cites W2326952490 @default.
- W2890946688 cites W2344746583 @default.
- W2890946688 cites W2405349986 @default.
- W2890946688 cites W2421919823 @default.
- W2890946688 cites W2510341570 @default.
- W2890946688 cites W2511481260 @default.
- W2890946688 cites W2549694731 @default.
- W2890946688 cites W2552872119 @default.
- W2890946688 cites W2561537919 @default.
- W2890946688 cites W2601560817 @default.
- W2890946688 cites W2602781259 @default.
- W2890946688 cites W2680762279 @default.
- W2890946688 cites W2758711215 @default.
- W2890946688 cites W2793544489 @default.
- W2890946688 cites W4242310196 @default.
- W2890946688 cites W4249759578 @default.
- W2890946688 cites W563482615 @default.
- W2890946688 doi "https://doi.org/10.1021/acs.bioconjchem.8b00509" @default.
- W2890946688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30185025" @default.