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- W2890949632 endingPage "73" @default.
- W2890949632 startingPage "60" @default.
- W2890949632 abstract "Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries for macromolecular targets. In the absence of an external stimulus, a dynamic library forms from reversibly reacting building blocks and reaches a stable thermodynamic equilibrium. However, upon addition of a macromolecular host which can bind and stabilize certain components of the library, the equilibrium composition changes and induces an evolution-like selection and enrichment of high-affinity ligands. A valuable application of this so-called target-directed DCC (tdDCC) is the identification of potent ligands for pharmacologically relevant targets. Over time, the term tdDCC has been applied to describe a number of different experimental setups, leading to some ambiguity concerning its definition. This article systematically classifies known procedures for tdDCC and related approaches, with a special focus on the methods used for analysis and evaluation of experiments." @default.
- W2890949632 created "2018-09-27" @default.
- W2890949632 creator A5015481785 @default.
- W2890949632 creator A5043008009 @default.
- W2890949632 creator A5077591315 @default.
- W2890949632 date "2018-12-11" @default.
- W2890949632 modified "2023-10-16" @default.
- W2890949632 title "Dynamic Combinatorial Chemistry: A New Methodology Comes of Age" @default.
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