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- W2890952992 abstract "Introduction: Sustained pathological sympathetic activation that accompanies heart failure (HF) contributes to the progression of myocardial injury and left ventricular (LV) dysfunction. Neprilysin (NEP) degrades natriuretic peptides (NP) and attenuates the beneficial effects of natriuretic peptide signaling. We utilized radiofrequency renal nerve denervation (RF-RDN) in a rodent model of hypertension and heart failure to investigate whether renal efferent activity regulates NEP activity and regulates NP levels and signaling. Methods: Spontaneously hypertensive rats (SHR) 20 weeks of age were subjected to 45 min of Left Anterior Descending coronary artery ligation followed by 12 weeks of reperfusion (Rep). 4 weeks following Rep, rats underwent either surgical bilateral radiofrequency RF-RDN (n=9) or sham RF-RDN (n=8) procedure (Biosense Webster Stockert 70 RF generator). Every 2 weeks, transthoracic echocardiograms were performed using Vevo 2100 (Visualsonics) to assess LV function. At 12 weeks plasma bra..." @default.
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- W2890952992 date "2016-11-11" @default.
- W2890952992 modified "2023-09-26" @default.
- W2890952992 title "Abstract 19164: Renal Sympathetic Denervation Modulates Natriuretic Peptides by Inhibiting Neprilysin in the Failing Heart" @default.
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