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• W2890955987 startingPage "7651" @default.
• W2890955987 abstract "Optical spectroscopy can be used to distinguish between healthy and diseased tissue. In this study, the design and testing of a single-pixel hyperspectral imaging (HSI) system that uses autofluorescence emission from collagen (400&#x00A0;nm) and nicotinamide adenine dinucleotide phosphate (475&#x00A0;nm) along with differences in the optical reflectance spectra to differentiate between healthy and thermally damaged tissue is discussed. The changes in protein autofluorescence and reflectance due to thermal damage are studied in ex vivo porcine tissue models. Thermal lesions were created in porcine skin (n=12) and liver (n=15) samples using an IR laser. The damaged regions were clearly visible in the hyperspectral images. Sizes of the thermally damaged regions as measured via HSI are compared to sizes of these regions as measured in white-light images and via physical measurement. Good agreement between the sizes measured in the hyperspectral images, white-light imaging, and physical measurements were found. The HSI system can differentiate between healthy and damaged tissue. Possible applications of this imaging system include determination of tumor margins during surgery/biopsy and cancer diagnosis and staging." @default.
• W2890955987 created "2018-09-27" @default.
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• W2890955987 date "2018-09-11" @default.
• W2890955987 modified "2023-09-29" @default.
• W2890955987 title "Hyperspectral imaging system based on a single-pixel camera design for detecting differences in tissue properties" @default.
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• W2890955987 doi "https://doi.org/10.1364/ao.57.007651" @default.
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