FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890964708> ?p ?o ?g. }

• W2890964708 abstract "A novel treatment regimen for bacterial infections is the pharmacological enhancement of the host's immune defenses. We demonstrated that biochanin A (BCA), an isoflavone constituent in some plants, could enhance both intra- and extracellular bactericidal activity of host cells. First, BCA could induce a complete autophagic response in nonphagocytic cells (HeLa) or macrophages (MΦ) via the AMPK/ULK1/mTOR pathway and Beclin-1-dependent manner, and BCA enhanced the killing of invading Salmonella by autophagy through reinforcing ubiquitinated adapter protein (LRSAM1, NDP52 and p62)-mediated recognition of intracellular bacteria and through the formation of autophagolysosomes. Second, we demonstrated that BCA could enhance the release of MΦ extracellular traps (METs) to remove extracellular Salmonella also via the AMPK/ULK1/mTOR pathway, not through reactive oxygen species (ROS) pathway. Furtherly, in a Salmonella-infected mouse model, BCA treatment increased intra- and extracellular bactericidal activity through the strengthening autophagy and MET production, respectively, in peritoneal MΦ, liver and spleen tissue. Additionally, our findings showed that BCA downregulated SPI-1 (Salmonella pathogenicity island 1) expression during Salmonella infection in vitro and in vivo to reverse the MΦ M2 polarization, which was different from the MΦ M1 phenotype caused by most of bacteria infection. Together, these findings suggest that BCA has an immunomodulatory effect on Salmonella-infected host cells and enhances their bactericidal activity in vitro and in vivo through autophagy, extracellular traps and regulation of MΦ polarization." @default.
• W2890964708 created "2018-09-27" @default.
• W2890964708 creator A5004524781 @default.
• W2890964708 creator A5013345074 @default.
• W2890964708 creator A5013832419 @default.
• W2890964708 creator A5017890959 @default.
• W2890964708 creator A5021234664 @default.
• W2890964708 creator A5032244758 @default.
• W2890964708 creator A5055203050 @default.
• W2890964708 creator A5055838753 @default.
• W2890964708 creator A5071329338 @default.
• W2890964708 creator A5074843339 @default.
• W2890964708 creator A5083412149 @default.
• W2890964708 creator A5086899185 @default.
• W2890964708 creator A5090960327 @default.
• W2890964708 date "2018-09-11" @default.
• W2890964708 modified "2023-10-16" @default.
• W2890964708 title "Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization" @default.
• W2890964708 cites W1523693806 @default.
• W2890964708 cites W1600560134 @default.
• W2890964708 cites W1930551399 @default.
• W2890964708 cites W1964055435 @default.
• W2890964708 cites W1964578013 @default.
• W2890964708 cites W1968068275 @default.
• W2890964708 cites W1970156474 @default.
• W2890964708 cites W1974844459 @default.
• W2890964708 cites W1975510193 @default.
• W2890964708 cites W1975705605 @default.
• W2890964708 cites W1982849914 @default.
• W2890964708 cites W1986900494 @default.
• W2890964708 cites W1991047945 @default.
• W2890964708 cites W1999810216 @default.
• W2890964708 cites W2012167979 @default.
• W2890964708 cites W2014678245 @default.
• W2890964708 cites W2014965592 @default.
• W2890964708 cites W2018795785 @default.
• W2890964708 cites W2023445018 @default.
• W2890964708 cites W2028419507 @default.
• W2890964708 cites W2043676813 @default.
• W2890964708 cites W2051912632 @default.
• W2890964708 cites W2059904733 @default.
• W2890964708 cites W2067946165 @default.
• W2890964708 cites W2074331191 @default.
• W2890964708 cites W2076941943 @default.
• W2890964708 cites W2091512988 @default.
• W2890964708 cites W2102823881 @default.
• W2890964708 cites W2103802234 @default.
• W2890964708 cites W2104934425 @default.
• W2890964708 cites W2108450330 @default.
• W2890964708 cites W2127634163 @default.
• W2890964708 cites W2132321106 @default.
• W2890964708 cites W2135574023 @default.
• W2890964708 cites W2153607816 @default.
• W2890964708 cites W2156171182 @default.
• W2890964708 cites W2161907636 @default.
• W2890964708 cites W2165250323 @default.
• W2890964708 cites W2166091310 @default.
• W2890964708 cites W2171726351 @default.
• W2890964708 cites W2172191543 @default.
• W2890964708 cites W2415268177 @default.
• W2890964708 cites W2491497270 @default.
• W2890964708 cites W2626425538 @default.
• W2890964708 cites W2686575608 @default.
• W2890964708 cites W2702812593 @default.
• W2890964708 cites W2750538807 @default.
• W2890964708 cites W574700172 @default.
• W2890964708 doi "https://doi.org/10.3389/fcimb.2018.00318" @default.
• W2890964708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142880" @default.
• W2890964708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271755" @default.
• W2890964708 hasPublicationYear "2018" @default.
• W2890964708 type Work @default.
• W2890964708 sameAs 2890964708 @default.
• W2890964708 citedByCount "39" @default.
• W2890964708 countsByYear W28909647082019 @default.
• W2890964708 countsByYear W28909647082020 @default.
• W2890964708 countsByYear W28909647082021 @default.
• W2890964708 countsByYear W28909647082022 @default.
• W2890964708 countsByYear W28909647082023 @default.
• W2890964708 crossrefType "journal-article" @default.
• W2890964708 hasAuthorship W2890964708A5004524781 @default.
• W2890964708 hasAuthorship W2890964708A5013345074 @default.
• W2890964708 hasAuthorship W2890964708A5013832419 @default.
• W2890964708 hasAuthorship W2890964708A5017890959 @default.
• W2890964708 hasAuthorship W2890964708A5021234664 @default.
• W2890964708 hasAuthorship W2890964708A5032244758 @default.
• W2890964708 hasAuthorship W2890964708A5055203050 @default.
• W2890964708 hasAuthorship W2890964708A5055838753 @default.
• W2890964708 hasAuthorship W2890964708A5071329338 @default.
• W2890964708 hasAuthorship W2890964708A5074843339 @default.
• W2890964708 hasAuthorship W2890964708A5083412149 @default.
• W2890964708 hasAuthorship W2890964708A5086899185 @default.
• W2890964708 hasAuthorship W2890964708A5090960327 @default.
• W2890964708 hasBestOaLocation W28909647081 @default.
• W2890964708 hasConcept C104317684 @default.
• W2890964708 hasConcept C145059251 @default.
• W2890964708 hasConcept C184235292 @default.
• W2890964708 hasConcept C190283241 @default.
• W2890964708 hasConcept C203014093 @default.
• W2890964708 hasConcept C203522944 @default.
• W2890964708 hasConcept C20518536 @default.

• next