Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890964876> ?p ?o ?g. }
- W2890964876 abstract "Abstract In this work, the effect of two key structural parameters, number of arms and arm length, of star‐shaped “structurally nanoengineered antimicrobial peptide polymers” (SNAPPs) on their antimicrobial activity and biocompatibility, is investigated. A library of star‐shaped SNAPPs is prepared, containing varying arm numbers and arm lengths. Antimicrobial assays are then performed to assess the capacity of the SNAPPs to disrupt the membrane, inhibit the growth, and kill pathogenic bacteria. A major finding of the study is that increasing arm number and length of SNAPPs enhanced antimicrobial activity, which can be respectively attributed to the higher local concentrations of polypeptide arms and increased α‐helical content. SNAPP architecture is shown to affect the bacteria membrane state and therefore mechanism of killing. Two more potent structures with up to twice the antimicrobial activity of the previously reported SNAPP are discovered in this process. Toxicities of the SNAPPs also increase with arm number and arm length, however therapeutic index calculations identified a 16‐arm SNAPP and an easier to prepare 4‐arm SNAPP as the best therapeutic agents. The biocompatibility of the SNAPP with the best biological activity is also evaluated in vivo, showing no markers of systemic damage in mice." @default.
- W2890964876 created "2018-09-27" @default.
- W2890964876 creator A5009966472 @default.
- W2890964876 creator A5018943607 @default.
- W2890964876 creator A5027806957 @default.
- W2890964876 creator A5031947830 @default.
- W2890964876 creator A5044751208 @default.
- W2890964876 creator A5047172005 @default.
- W2890964876 creator A5083906418 @default.
- W2890964876 date "2018-09-02" @default.
- W2890964876 modified "2023-09-25" @default.
- W2890964876 title "Architectural Effects of Star‐Shaped “Structurally Nanoengineered Antimicrobial Peptide Polymers” (SNAPPs) on Their Biological Activity" @default.
- W2890964876 cites W1553047467 @default.
- W2890964876 cites W1597963080 @default.
- W2890964876 cites W1847977338 @default.
- W2890964876 cites W1971940819 @default.
- W2890964876 cites W1972140606 @default.
- W2890964876 cites W1979973356 @default.
- W2890964876 cites W1983785810 @default.
- W2890964876 cites W1989712461 @default.
- W2890964876 cites W1989998611 @default.
- W2890964876 cites W1992620470 @default.
- W2890964876 cites W1996571225 @default.
- W2890964876 cites W1997152791 @default.
- W2890964876 cites W1997961222 @default.
- W2890964876 cites W2012893255 @default.
- W2890964876 cites W2017034912 @default.
- W2890964876 cites W2024246208 @default.
- W2890964876 cites W2025938842 @default.
- W2890964876 cites W2033165043 @default.
- W2890964876 cites W2035327865 @default.
- W2890964876 cites W2042906495 @default.
- W2890964876 cites W2054602599 @default.
- W2890964876 cites W2064683586 @default.
- W2890964876 cites W2066216362 @default.
- W2890964876 cites W2068469652 @default.
- W2890964876 cites W2071389857 @default.
- W2890964876 cites W2087167599 @default.
- W2890964876 cites W2089377837 @default.
- W2890964876 cites W2094367222 @default.
- W2890964876 cites W2097099115 @default.
- W2890964876 cites W2112484264 @default.
- W2890964876 cites W2113705643 @default.
- W2890964876 cites W2117087393 @default.
- W2890964876 cites W2126957299 @default.
- W2890964876 cites W2145723948 @default.
- W2890964876 cites W2160171025 @default.
- W2890964876 cites W2239738725 @default.
- W2890964876 cites W2300011769 @default.
- W2890964876 cites W2318933922 @default.
- W2890964876 cites W2321474702 @default.
- W2890964876 cites W2330503753 @default.
- W2890964876 cites W2332561457 @default.
- W2890964876 cites W2519871290 @default.
- W2890964876 cites W4210968711 @default.
- W2890964876 cites W4246732698 @default.
- W2890964876 cites W1999938456 @default.
- W2890964876 doi "https://doi.org/10.1002/adhm.201800627" @default.
- W2890964876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30175464" @default.
- W2890964876 hasPublicationYear "2018" @default.
- W2890964876 type Work @default.
- W2890964876 sameAs 2890964876 @default.
- W2890964876 citedByCount "40" @default.
- W2890964876 countsByYear W28909648762019 @default.
- W2890964876 countsByYear W28909648762020 @default.
- W2890964876 countsByYear W28909648762021 @default.
- W2890964876 countsByYear W28909648762022 @default.
- W2890964876 countsByYear W28909648762023 @default.
- W2890964876 crossrefType "journal-article" @default.
- W2890964876 hasAuthorship W2890964876A5009966472 @default.
- W2890964876 hasAuthorship W2890964876A5018943607 @default.
- W2890964876 hasAuthorship W2890964876A5027806957 @default.
- W2890964876 hasAuthorship W2890964876A5031947830 @default.
- W2890964876 hasAuthorship W2890964876A5044751208 @default.
- W2890964876 hasAuthorship W2890964876A5047172005 @default.
- W2890964876 hasAuthorship W2890964876A5083906418 @default.
- W2890964876 hasBestOaLocation W28909648762 @default.
- W2890964876 hasConcept C116073593 @default.
- W2890964876 hasConcept C12554922 @default.
- W2890964876 hasConcept C150903083 @default.
- W2890964876 hasConcept C171250308 @default.
- W2890964876 hasConcept C178790620 @default.
- W2890964876 hasConcept C185592680 @default.
- W2890964876 hasConcept C192562407 @default.
- W2890964876 hasConcept C202751555 @default.
- W2890964876 hasConcept C207001950 @default.
- W2890964876 hasConcept C21951064 @default.
- W2890964876 hasConcept C2777230088 @default.
- W2890964876 hasConcept C2779281246 @default.
- W2890964876 hasConcept C2994355463 @default.
- W2890964876 hasConcept C41625074 @default.
- W2890964876 hasConcept C44228677 @default.
- W2890964876 hasConcept C4937899 @default.
- W2890964876 hasConcept C521977710 @default.
- W2890964876 hasConcept C523546767 @default.
- W2890964876 hasConcept C540938839 @default.
- W2890964876 hasConcept C54355233 @default.
- W2890964876 hasConcept C55493867 @default.
- W2890964876 hasConcept C86803240 @default.
- W2890964876 hasConcept C89423630 @default.