Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890969894> ?p ?o ?g. }
- W2890969894 endingPage "1093" @default.
- W2890969894 startingPage "1083" @default.
- W2890969894 abstract "Cervical adenocarcinomas are believed to lose estrogen response on the basis of no expression of a nuclear estrogen receptor such as ERα in clinical pathology. Here, we demonstrated that cervical adenocarcinoma cells respond to a physiological concentration of estrogen to upregulate claudin-1, a cell surface molecule highly expressed in cervical adenocarcinomas. Knockout of claudin-1 induced apoptosis and significantly inhibited proliferation, migration, and invasion of cervical adenocarcinoma cells and tumorigenicity in vivo. Importantly, all of the cervical adenocarcinoma cell lines examined expressed a membrane-bound type estrogen receptor, G protein–coupled receptor 30 (GPR30/GPER1), but not ERα. Estrogen-dependent induction of claudin-1 expression was mediated by GPR30 via ERK and/or Akt signaling. In surgical specimens, there was a positive correlation between claudin-1 expression and GPR30 expression. Double high expression of claudin-1 and GPR30 predicts poor prognosis in patients with cervical adenocarcinomas. Mechanism-based targeting of estrogen/GPR30 signaling and claudin-1 may be effective for cervical adenocarcinoma therapy." @default.
- W2890969894 created "2018-09-27" @default.
- W2890969894 creator A5011988426 @default.
- W2890969894 creator A5021146724 @default.
- W2890969894 creator A5042132739 @default.
- W2890969894 creator A5053483373 @default.
- W2890969894 creator A5056654750 @default.
- W2890969894 creator A5065232072 @default.
- W2890969894 creator A5068146731 @default.
- W2890969894 creator A5071632526 @default.
- W2890969894 date "2018-10-01" @default.
- W2890969894 modified "2023-10-16" @default.
- W2890969894 title "Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression" @default.
- W2890969894 cites W1566189373 @default.
- W2890969894 cites W1966021538 @default.
- W2890969894 cites W1972086601 @default.
- W2890969894 cites W1976678368 @default.
- W2890969894 cites W1982533501 @default.
- W2890969894 cites W1990578192 @default.
- W2890969894 cites W1998640066 @default.
- W2890969894 cites W1999207866 @default.
- W2890969894 cites W2012644882 @default.
- W2890969894 cites W2016548770 @default.
- W2890969894 cites W2016808506 @default.
- W2890969894 cites W2023084443 @default.
- W2890969894 cites W2025008638 @default.
- W2890969894 cites W2025400136 @default.
- W2890969894 cites W2033040258 @default.
- W2890969894 cites W2038056767 @default.
- W2890969894 cites W2057398439 @default.
- W2890969894 cites W2076942915 @default.
- W2890969894 cites W2077137418 @default.
- W2890969894 cites W2092184448 @default.
- W2890969894 cites W2095088551 @default.
- W2890969894 cites W2099530558 @default.
- W2890969894 cites W2100784179 @default.
- W2890969894 cites W2114980230 @default.
- W2890969894 cites W2121960517 @default.
- W2890969894 cites W2137207319 @default.
- W2890969894 cites W2137681063 @default.
- W2890969894 cites W2144597628 @default.
- W2890969894 cites W2145782793 @default.
- W2890969894 cites W2154037084 @default.
- W2890969894 cites W2164804511 @default.
- W2890969894 cites W2186784163 @default.
- W2890969894 cites W2407842430 @default.
- W2890969894 cites W2409001986 @default.
- W2890969894 cites W2521310896 @default.
- W2890969894 cites W2561157373 @default.
- W2890969894 cites W2576676890 @default.
- W2890969894 cites W2591717879 @default.
- W2890969894 cites W3148607889 @default.
- W2890969894 cites W347656695 @default.
- W2890969894 doi "https://doi.org/10.1016/j.neo.2018.08.010" @default.
- W2890969894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6141703" @default.
- W2890969894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227306" @default.
- W2890969894 hasPublicationYear "2018" @default.
- W2890969894 type Work @default.
- W2890969894 sameAs 2890969894 @default.
- W2890969894 citedByCount "22" @default.
- W2890969894 countsByYear W28909698942019 @default.
- W2890969894 countsByYear W28909698942020 @default.
- W2890969894 countsByYear W28909698942021 @default.
- W2890969894 countsByYear W28909698942022 @default.
- W2890969894 countsByYear W28909698942023 @default.
- W2890969894 crossrefType "journal-article" @default.
- W2890969894 hasAuthorship W2890969894A5011988426 @default.
- W2890969894 hasAuthorship W2890969894A5021146724 @default.
- W2890969894 hasAuthorship W2890969894A5042132739 @default.
- W2890969894 hasAuthorship W2890969894A5053483373 @default.
- W2890969894 hasAuthorship W2890969894A5056654750 @default.
- W2890969894 hasAuthorship W2890969894A5065232072 @default.
- W2890969894 hasAuthorship W2890969894A5068146731 @default.
- W2890969894 hasAuthorship W2890969894A5071632526 @default.
- W2890969894 hasBestOaLocation W28909698941 @default.
- W2890969894 hasConcept C121608353 @default.
- W2890969894 hasConcept C126322002 @default.
- W2890969894 hasConcept C134018914 @default.
- W2890969894 hasConcept C166471694 @default.
- W2890969894 hasConcept C172313692 @default.
- W2890969894 hasConcept C177779419 @default.
- W2890969894 hasConcept C2777164284 @default.
- W2890969894 hasConcept C2781182431 @default.
- W2890969894 hasConcept C502942594 @default.
- W2890969894 hasConcept C51872919 @default.
- W2890969894 hasConcept C530470458 @default.
- W2890969894 hasConcept C71924100 @default.
- W2890969894 hasConcept C84606932 @default.
- W2890969894 hasConcept C86803240 @default.
- W2890969894 hasConcept C95444343 @default.
- W2890969894 hasConcept C96307122 @default.
- W2890969894 hasConceptScore W2890969894C121608353 @default.
- W2890969894 hasConceptScore W2890969894C126322002 @default.
- W2890969894 hasConceptScore W2890969894C134018914 @default.
- W2890969894 hasConceptScore W2890969894C166471694 @default.
- W2890969894 hasConceptScore W2890969894C172313692 @default.
- W2890969894 hasConceptScore W2890969894C177779419 @default.
- W2890969894 hasConceptScore W2890969894C2777164284 @default.