Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890970781> ?p ?o ?g. }
- W2890970781 abstract "Abstract Genetic studies have shown that FGF10/FGFR2 signaling is required for airway branching morphogenesis and FGF10 functions as a chemoattractant factor for distal epithelial cells during lung development. However, the detail downstream cellular and molecular mechanisms have not been fully characterized. Using live imaging of ex vivo cultured lungs, we found that tip airway epithelial progenitor cells migrate faster than cleft cells during airway bud formation and this migration process is controlled by FGFR2-mediated ERK1/2 signaling. Additionally, we found that airway progenitor cells that migrate faster tend to become distal airway progenitor cells. We identified that Anxa4 is a downstream target of ERK1/2 signaling. Anxa4 −/− airway epithelial cells exhibit a “lag-behind” behavior and tend to stay at the stalk airways. Moreover, we found that Anxa4 -overexpressing cells tend to migrate to the bud tips. Finally, we demonstrated that Anxa4 functions redundantly with Anxa1 and Anxa6 in regulating endoderm budding process. Our study demonstrates that ERK1/2/Anxa4 signaling plays a role in promoting the migration of airway epithelial progenitor cells to distal airway tips and ensuring their distal cell fate." @default.
- W2890970781 created "2018-09-27" @default.
- W2890970781 creator A5000448631 @default.
- W2890970781 creator A5031357425 @default.
- W2890970781 creator A5062243169 @default.
- W2890970781 creator A5064711465 @default.
- W2890970781 creator A5086866538 @default.
- W2890970781 date "2018-09-25" @default.
- W2890970781 modified "2023-10-05" @default.
- W2890970781 title "Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification" @default.
- W2890970781 cites W1575984269 @default.
- W2890970781 cites W1604221810 @default.
- W2890970781 cites W1903617196 @default.
- W2890970781 cites W1932669647 @default.
- W2890970781 cites W1963750365 @default.
- W2890970781 cites W1965358479 @default.
- W2890970781 cites W1969920944 @default.
- W2890970781 cites W1976275386 @default.
- W2890970781 cites W1976835478 @default.
- W2890970781 cites W1978596841 @default.
- W2890970781 cites W1987745427 @default.
- W2890970781 cites W1988476050 @default.
- W2890970781 cites W1990852843 @default.
- W2890970781 cites W1995620639 @default.
- W2890970781 cites W1996416783 @default.
- W2890970781 cites W1997948433 @default.
- W2890970781 cites W2001508112 @default.
- W2890970781 cites W2007413389 @default.
- W2890970781 cites W2018105009 @default.
- W2890970781 cites W2029976193 @default.
- W2890970781 cites W2046445536 @default.
- W2890970781 cites W2052350776 @default.
- W2890970781 cites W2052723831 @default.
- W2890970781 cites W2072680267 @default.
- W2890970781 cites W2073228761 @default.
- W2890970781 cites W2074655501 @default.
- W2890970781 cites W2074978112 @default.
- W2890970781 cites W2077789771 @default.
- W2890970781 cites W2088080018 @default.
- W2890970781 cites W2093208620 @default.
- W2890970781 cites W2104010513 @default.
- W2890970781 cites W2106654391 @default.
- W2890970781 cites W2110042849 @default.
- W2890970781 cites W2117248052 @default.
- W2890970781 cites W2120068964 @default.
- W2890970781 cites W2128785312 @default.
- W2890970781 cites W2129766218 @default.
- W2890970781 cites W2133054656 @default.
- W2890970781 cites W2149275036 @default.
- W2890970781 cites W2151868528 @default.
- W2890970781 cites W2154294808 @default.
- W2890970781 cites W2159545748 @default.
- W2890970781 cites W2160272259 @default.
- W2890970781 cites W2160310800 @default.
- W2890970781 cites W2161282017 @default.
- W2890970781 cites W2179848725 @default.
- W2890970781 cites W2238445461 @default.
- W2890970781 cites W2282517414 @default.
- W2890970781 cites W2304754051 @default.
- W2890970781 cites W2783102953 @default.
- W2890970781 cites W2787299394 @default.
- W2890970781 doi "https://doi.org/10.1038/s41598-018-32494-z" @default.
- W2890970781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156511" @default.
- W2890970781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254199" @default.
- W2890970781 hasPublicationYear "2018" @default.
- W2890970781 type Work @default.
- W2890970781 sameAs 2890970781 @default.
- W2890970781 citedByCount "10" @default.
- W2890970781 countsByYear W28909707812019 @default.
- W2890970781 countsByYear W28909707812021 @default.
- W2890970781 countsByYear W28909707812022 @default.
- W2890970781 countsByYear W28909707812023 @default.
- W2890970781 crossrefType "journal-article" @default.
- W2890970781 hasAuthorship W2890970781A5000448631 @default.
- W2890970781 hasAuthorship W2890970781A5031357425 @default.
- W2890970781 hasAuthorship W2890970781A5062243169 @default.
- W2890970781 hasAuthorship W2890970781A5064711465 @default.
- W2890970781 hasAuthorship W2890970781A5086866538 @default.
- W2890970781 hasBestOaLocation W28909707811 @default.
- W2890970781 hasConcept C104317684 @default.
- W2890970781 hasConcept C105702510 @default.
- W2890970781 hasConcept C105922876 @default.
- W2890970781 hasConcept C137738243 @default.
- W2890970781 hasConcept C141071460 @default.
- W2890970781 hasConcept C146759223 @default.
- W2890970781 hasConcept C1491633281 @default.
- W2890970781 hasConcept C15729860 @default.
- W2890970781 hasConcept C163952510 @default.
- W2890970781 hasConcept C170493617 @default.
- W2890970781 hasConcept C201750760 @default.
- W2890970781 hasConcept C28328180 @default.
- W2890970781 hasConcept C40692019 @default.
- W2890970781 hasConcept C529295009 @default.
- W2890970781 hasConcept C54355233 @default.
- W2890970781 hasConcept C71924100 @default.
- W2890970781 hasConcept C74373430 @default.
- W2890970781 hasConcept C86339819 @default.
- W2890970781 hasConcept C86803240 @default.
- W2890970781 hasConcept C87568996 @default.
- W2890970781 hasConcept C95444343 @default.