FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890972231> ?p ?o ?g. }

• W2890972231 endingPage "28" @default.
• W2890972231 startingPage "20" @default.
• W2890972231 abstract "The splicing factor SPF45 (RBM17) is a well-known component of the spliceosome that is involved in alternative splicing. RBM17 is frequently overexpressed in many tumors and plays a crucial role in cancer progression and drug resistance. However, the role of RBM17 in the development of glioma has not been thoroughly elucidated to date. In the present study, we found that RBM17 was overexpressed in glioma and that a high level of expression of RBM17 was closely associated with a poor prognosis in glioma patients. We investigated the effect of RBM17 on apoptosis, cell growth and cell cycle indexes and the activation of apoptosis signaling by shRNA in human U87 and U251 glioma cells. The downregulated expression of RBM17 mRNA was accompanied by the induction of cell cycle arrest, and apoptosis, reduced cell proliferation in the two cell lines, and reduced cell survival, as measured by the increased activation of caspase-3, caspase-9, and PARP (poly ADP-ribose polymerase). Furthermore, in subcutaneous U87 cell xenograft tumors in nude mice, intradermal administration of an shRNA targeting RBM17 significantly downregulated RBM17 expression in vivo and was accompanied by the suppressed growth of glioma. To the best of our knowledge, our results are the first to confirm that RBM17 functions in promoting cell proliferation, affecting the cell cycle, and inducing apoptosis in human glioma cells both in vitro and in vivo. These results indicate that RBM17 may be a therapeutic target in the clinical management of glioma." @default.
• W2890972231 created "2018-09-27" @default.
• W2890972231 creator A5002903408 @default.
• W2890972231 creator A5012623727 @default.
• W2890972231 creator A5015614663 @default.
• W2890972231 creator A5016604263 @default.
• W2890972231 creator A5047314500 @default.
• W2890972231 creator A5051586443 @default.
• W2890972231 creator A5060250527 @default.
• W2890972231 creator A5061827319 @default.
• W2890972231 creator A5066887020 @default.
• W2890972231 creator A5079911251 @default.
• W2890972231 creator A5085017406 @default.
• W2890972231 creator A5085764907 @default.
• W2890972231 date "2018-10-01" @default.
• W2890972231 modified "2023-10-14" @default.
• W2890972231 title "RBM17 controls apoptosis and proliferation to promote Glioma progression" @default.
• W2890972231 cites W115580540 @default.
• W2890972231 cites W1546538401 @default.
• W2890972231 cites W1642763135 @default.
• W2890972231 cites W1971873029 @default.
• W2890972231 cites W1973792489 @default.
• W2890972231 cites W1975061879 @default.
• W2890972231 cites W1975336660 @default.
• W2890972231 cites W2008962735 @default.
• W2890972231 cites W2011920499 @default.
• W2890972231 cites W2013881430 @default.
• W2890972231 cites W2016345107 @default.
• W2890972231 cites W2036044314 @default.
• W2890972231 cites W2043435109 @default.
• W2890972231 cites W2065572350 @default.
• W2890972231 cites W2068274700 @default.
• W2890972231 cites W2068816187 @default.
• W2890972231 cites W2073683821 @default.
• W2890972231 cites W2077723816 @default.
• W2890972231 cites W2101636442 @default.
• W2890972231 cites W2106704637 @default.
• W2890972231 cites W2110524342 @default.
• W2890972231 cites W2134064455 @default.
• W2890972231 cites W2141055671 @default.
• W2890972231 cites W2153945694 @default.
• W2890972231 cites W2155922793 @default.
• W2890972231 cites W2158734599 @default.
• W2890972231 cites W2537398264 @default.
• W2890972231 cites W2606183535 @default.
• W2890972231 cites W37630318 @default.
• W2890972231 doi "https://doi.org/10.1016/j.bbrc.2018.09.056" @default.
• W2890972231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227940" @default.
• W2890972231 hasPublicationYear "2018" @default.
• W2890972231 type Work @default.
• W2890972231 sameAs 2890972231 @default.
• W2890972231 citedByCount "11" @default.
• W2890972231 countsByYear W28909722312020 @default.
• W2890972231 countsByYear W28909722312021 @default.
• W2890972231 countsByYear W28909722312022 @default.
• W2890972231 countsByYear W28909722312023 @default.
• W2890972231 crossrefType "journal-article" @default.
• W2890972231 hasAuthorship W2890972231A5002903408 @default.
• W2890972231 hasAuthorship W2890972231A5012623727 @default.
• W2890972231 hasAuthorship W2890972231A5015614663 @default.
• W2890972231 hasAuthorship W2890972231A5016604263 @default.
• W2890972231 hasAuthorship W2890972231A5047314500 @default.
• W2890972231 hasAuthorship W2890972231A5051586443 @default.
• W2890972231 hasAuthorship W2890972231A5060250527 @default.
• W2890972231 hasAuthorship W2890972231A5061827319 @default.
• W2890972231 hasAuthorship W2890972231A5066887020 @default.
• W2890972231 hasAuthorship W2890972231A5079911251 @default.
• W2890972231 hasAuthorship W2890972231A5085017406 @default.
• W2890972231 hasAuthorship W2890972231A5085764907 @default.
• W2890972231 hasConcept C105696609 @default.
• W2890972231 hasConcept C128473837 @default.
• W2890972231 hasConcept C1491633281 @default.
• W2890972231 hasConcept C173396325 @default.
• W2890972231 hasConcept C190232843 @default.
• W2890972231 hasConcept C190283241 @default.
• W2890972231 hasConcept C2778227246 @default.
• W2890972231 hasConcept C29537977 @default.
• W2890972231 hasConcept C502942594 @default.
• W2890972231 hasConcept C55493867 @default.
• W2890972231 hasConcept C62112901 @default.
• W2890972231 hasConcept C86803240 @default.
• W2890972231 hasConceptScore W2890972231C105696609 @default.
• W2890972231 hasConceptScore W2890972231C128473837 @default.
• W2890972231 hasConceptScore W2890972231C1491633281 @default.
• W2890972231 hasConceptScore W2890972231C173396325 @default.
• W2890972231 hasConceptScore W2890972231C190232843 @default.
• W2890972231 hasConceptScore W2890972231C190283241 @default.
• W2890972231 hasConceptScore W2890972231C2778227246 @default.
• W2890972231 hasConceptScore W2890972231C29537977 @default.
• W2890972231 hasConceptScore W2890972231C502942594 @default.
• W2890972231 hasConceptScore W2890972231C55493867 @default.
• W2890972231 hasConceptScore W2890972231C62112901 @default.
• W2890972231 hasConceptScore W2890972231C86803240 @default.
• W2890972231 hasFunder F4320321001 @default.
• W2890972231 hasFunder F4320324224 @default.
• W2890972231 hasIssue "1" @default.
• W2890972231 hasLocation W28909722311 @default.
• W2890972231 hasLocation W28909722312 @default.

• next