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- W2890972345 endingPage "2414" @default.
- W2890972345 startingPage "2414" @default.
- W2890972345 abstract "Scaffolds can be considered as one of the most promising treatments for bone tissue regeneration. Herein, blends of chitosan, poly(vinyl alcohol), and hydroxyapatite in different ratios were used to synthesize scaffolds via freeze-drying. Mechanical tests, FTIR, swelling and solubility degree, DSC, morphology, and cell viability were used as characterization techniques. Statistical significance of the experiments was determined using a two-way analysis of variance (ANOVA) with p < 0.05. Crosslinked and plasticized scaffolds absorbed five times more water than non-crosslinked and plasticized ones, which is an indicator of better hydrophilic features, as well as adequate resistance to water without detriment of the swelling potential. Indeed, the tested mechanical properties were notably higher for samples which were undergone to crosslinking and plasticized process. The presence of chitosan is determinant in pore formation and distribution which is an imperative for cell communication. Uniform pore size with diameters ranging from 142 to 519 µm were obtained, a range that has been described as optimal for bone tissue regeneration. Moreover, cytotoxicity was considered as negligible in the tested conditions, and viability indicates that the material might have potential as a bone regeneration system." @default.
- W2890972345 created "2018-09-27" @default.
- W2890972345 creator A5007075883 @default.
- W2890972345 creator A5017215126 @default.
- W2890972345 creator A5029711543 @default.
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- W2890972345 creator A5052694801 @default.
- W2890972345 creator A5064734713 @default.
- W2890972345 creator A5074658904 @default.
- W2890972345 creator A5082670363 @default.
- W2890972345 date "2018-09-20" @default.
- W2890972345 modified "2023-09-24" @default.
- W2890972345 title "Synthesis and Characterization of Poly(Vinyl Alcohol)-Chitosan-Hydroxyapatite Scaffolds: A Promising Alternative for Bone Tissue Regeneration" @default.
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- W2890972345 doi "https://doi.org/10.3390/molecules23102414" @default.