Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890973164> ?p ?o ?g. }
- W2890973164 abstract "Protein glycosylation pathways have been identified in a variety of bacteria and are best understood in pathogens and commensals in which the glycosylation targets are cell surface proteins, such as S layers, pili, and flagella. In contrast, very little is known about the glycosylation of bacterial enzymes, especially those secreted by cellulolytic bacteria. Caldicellulosiruptor bescii secretes several unique synergistic multifunctional biomass-degrading enzymes, notably cellulase A which is largely responsible for this organism's ability to grow on lignocellulosic biomass without the conventional pretreatment. It was recently discovered that extracellular CelA is heavily glycosylated. In this work, we identified an O-glycosyltransferase in the C. bescii chromosome and targeted it for deletion. The resulting mutant was unable to grow on crystalline cellulose and showed no detectable protein glycosylation. Multifunctional biomass-degrading enzymes in this strain were rapidly degraded. With the genetic tools available in C. bescii, this system represents a unique opportunity to study the role of bacterial enzyme glycosylation as well an investigation of the pathway for protein glycosylation in a non-pathogen." @default.
- W2890973164 created "2018-09-27" @default.
- W2890973164 creator A5006644300 @default.
- W2890973164 creator A5013047074 @default.
- W2890973164 creator A5013719737 @default.
- W2890973164 creator A5017401925 @default.
- W2890973164 creator A5024717527 @default.
- W2890973164 creator A5041559766 @default.
- W2890973164 creator A5044251446 @default.
- W2890973164 creator A5076815423 @default.
- W2890973164 date "2018-09-24" @default.
- W2890973164 modified "2023-09-25" @default.
- W2890973164 title "Deletion of a single glycosyltransferase in Caldicellulosiruptor bescii eliminates protein glycosylation and growth on crystalline cellulose" @default.
- W2890973164 cites W1846019140 @default.
- W2890973164 cites W1971147414 @default.
- W2890973164 cites W1972435343 @default.
- W2890973164 cites W1977950017 @default.
- W2890973164 cites W1978096145 @default.
- W2890973164 cites W1995191746 @default.
- W2890973164 cites W1996202622 @default.
- W2890973164 cites W2013132274 @default.
- W2890973164 cites W2014509414 @default.
- W2890973164 cites W2017389387 @default.
- W2890973164 cites W2041258165 @default.
- W2890973164 cites W2049230219 @default.
- W2890973164 cites W2049470922 @default.
- W2890973164 cites W2049835823 @default.
- W2890973164 cites W2060168049 @default.
- W2890973164 cites W2063121202 @default.
- W2890973164 cites W2075797628 @default.
- W2890973164 cites W2091812491 @default.
- W2890973164 cites W2102531682 @default.
- W2890973164 cites W2103540045 @default.
- W2890973164 cites W2104745339 @default.
- W2890973164 cites W2113321146 @default.
- W2890973164 cites W2114926981 @default.
- W2890973164 cites W2116581415 @default.
- W2890973164 cites W2116740734 @default.
- W2890973164 cites W2116817862 @default.
- W2890973164 cites W2116840946 @default.
- W2890973164 cites W2122559203 @default.
- W2890973164 cites W2123520920 @default.
- W2890973164 cites W2124890511 @default.
- W2890973164 cites W2131538335 @default.
- W2890973164 cites W2141286748 @default.
- W2890973164 cites W2143926699 @default.
- W2890973164 cites W2146884073 @default.
- W2890973164 cites W2149595091 @default.
- W2890973164 cites W2156512781 @default.
- W2890973164 cites W2160197593 @default.
- W2890973164 cites W2164106355 @default.
- W2890973164 cites W2747489921 @default.
- W2890973164 cites W2761798405 @default.
- W2890973164 cites W2774296474 @default.
- W2890973164 cites W2791151778 @default.
- W2890973164 cites W3206313421 @default.
- W2890973164 cites W4253267427 @default.
- W2890973164 doi "https://doi.org/10.1186/s13068-018-1266-x" @default.
- W2890973164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151902" @default.
- W2890973164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30258493" @default.
- W2890973164 hasPublicationYear "2018" @default.
- W2890973164 type Work @default.
- W2890973164 sameAs 2890973164 @default.
- W2890973164 citedByCount "9" @default.
- W2890973164 countsByYear W28909731642019 @default.
- W2890973164 countsByYear W28909731642020 @default.
- W2890973164 countsByYear W28909731642021 @default.
- W2890973164 countsByYear W28909731642023 @default.
- W2890973164 crossrefType "journal-article" @default.
- W2890973164 hasAuthorship W2890973164A5006644300 @default.
- W2890973164 hasAuthorship W2890973164A5013047074 @default.
- W2890973164 hasAuthorship W2890973164A5013719737 @default.
- W2890973164 hasAuthorship W2890973164A5017401925 @default.
- W2890973164 hasAuthorship W2890973164A5024717527 @default.
- W2890973164 hasAuthorship W2890973164A5041559766 @default.
- W2890973164 hasAuthorship W2890973164A5044251446 @default.
- W2890973164 hasAuthorship W2890973164A5076815423 @default.
- W2890973164 hasBestOaLocation W28909731641 @default.
- W2890973164 hasConcept C104317684 @default.
- W2890973164 hasConcept C141603559 @default.
- W2890973164 hasConcept C143065580 @default.
- W2890973164 hasConcept C161019410 @default.
- W2890973164 hasConcept C181199279 @default.
- W2890973164 hasConcept C185592680 @default.
- W2890973164 hasConcept C196032511 @default.
- W2890973164 hasConcept C2777313579 @default.
- W2890973164 hasConcept C2778234585 @default.
- W2890973164 hasConcept C2779251873 @default.
- W2890973164 hasConcept C523546767 @default.
- W2890973164 hasConcept C54355233 @default.
- W2890973164 hasConcept C55493867 @default.
- W2890973164 hasConcept C86803240 @default.
- W2890973164 hasConcept C89423630 @default.
- W2890973164 hasConceptScore W2890973164C104317684 @default.
- W2890973164 hasConceptScore W2890973164C141603559 @default.
- W2890973164 hasConceptScore W2890973164C143065580 @default.
- W2890973164 hasConceptScore W2890973164C161019410 @default.
- W2890973164 hasConceptScore W2890973164C181199279 @default.
- W2890973164 hasConceptScore W2890973164C185592680 @default.
- W2890973164 hasConceptScore W2890973164C196032511 @default.