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- W289097404 abstract "The Na + –Ca 2+ exchanger (NCX) is a membrane protein that utilizes the electrochemical gradient for Na + to extrude Ca 2+ from the cell. As a Ca 2+ efflux mechanism, NCX plays a prominent role in the maintenance of Ca 2+ homeostasis in a variety of tissues. It is composed of 938 amino acids organized into nine transmembrane segments (TMSs). The first five TMSs are separated from the last four by a large intracellular loop, which comprises more than half of the exchanger. While the transmembrane segments carry out ion transport, the large intracellular loop is involved in regulatory processes. This includes modulation of NCX activity by cytoplasmic factors such as Na + , Ca 2+ , H + , adenosine triphosphate (ATP), and lipids." @default.
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- W289097404 date "2013-01-01" @default.
- W289097404 modified "2023-09-28" @default.
- W289097404 title "Sodium–Calcium Exchanger: Structural Aspects" @default.
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- W289097404 doi "https://doi.org/10.1016/b978-0-12-378630-2.00230-9" @default.
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