FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890975982> ?p ?o ?g. }

• W2890975982 endingPage "e1007296" @default.
• W2890975982 startingPage "e1007296" @default.
• W2890975982 abstract "SARS-coronavirus (CoV) is a zoonotic agent derived from rhinolophid bats, in which a plethora of SARS-related, conspecific viral lineages exist. Whereas the variability of virulence among reservoir-borne viruses is unknown, it is generally assumed that the emergence of epidemic viruses from animal reservoirs requires human adaptation. To understand the influence of a viral factor in relation to interspecies spillover, we studied the papain-like protease (PLP) of SARS-CoV. This key enzyme drives the early stages of infection as it cleaves the viral polyprotein, deubiquitinates viral and cellular proteins, and antagonizes the interferon (IFN) response. We identified a bat SARS-CoV PLP, which shared 86% amino acid identity with SARS-CoV PLP, and used reverse genetics to insert it into the SARS-CoV genome. The resulting virus replicated like SARS-CoV in Vero cells but was suppressed in IFN competent MA-104 (3.7-fold), Calu-3 (2.6-fold) and human airway epithelial cells (10.3-fold). Using ectopically-expressed PLP variants as well as full SARS-CoV infectious clones chimerized for PLP, we found that a protease-independent, anti-IFN function exists in SARS-CoV, but not in a SARS-related, bat-borne virus. This PLP-mediated anti-IFN difference was seen in primate, human as well as bat cells, thus independent of the host context. The results of this study revealed that coronavirus PLP confers a variable virulence trait among members of the species SARS-CoV, and that a SARS-CoV lineage with virulent PLPs may have pre-existed in the reservoir before onset of the epidemic." @default.
• W2890975982 created "2018-09-27" @default.
• W2890975982 creator A5004564974 @default.
• W2890975982 creator A5006074825 @default.
• W2890975982 creator A5011461272 @default.
• W2890975982 creator A5012396670 @default.
• W2890975982 creator A5026764176 @default.
• W2890975982 creator A5038278924 @default.
• W2890975982 creator A5041846756 @default.
• W2890975982 creator A5056909452 @default.
• W2890975982 creator A5066590498 @default.
• W2890975982 creator A5084315586 @default.
• W2890975982 date "2018-09-24" @default.
• W2890975982 modified "2023-10-06" @default.
• W2890975982 title "The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species" @default.
• W2890975982 cites W1852588318 @default.
• W2890975982 cites W190626844 @default.
• W2890975982 cites W1964626485 @default.
• W2890975982 cites W1966504197 @default.
• W2890975982 cites W1967407510 @default.
• W2890975982 cites W1972126235 @default.
• W2890975982 cites W1976483167 @default.
• W2890975982 cites W1978173716 @default.
• W2890975982 cites W1990059132 @default.
• W2890975982 cites W1990554834 @default.
• W2890975982 cites W1992509320 @default.
• W2890975982 cites W1993577573 @default.
• W2890975982 cites W1994845424 @default.
• W2890975982 cites W1996909392 @default.
• W2890975982 cites W2005263607 @default.
• W2890975982 cites W2015000228 @default.
• W2890975982 cites W2020816047 @default.
• W2890975982 cites W2022879707 @default.
• W2890975982 cites W2031182394 @default.
• W2890975982 cites W2031705962 @default.
• W2890975982 cites W2034133457 @default.
• W2890975982 cites W2038481705 @default.
• W2890975982 cites W2039228041 @default.
• W2890975982 cites W2050963689 @default.
• W2890975982 cites W2051636160 @default.
• W2890975982 cites W2053473486 @default.
• W2890975982 cites W2060027762 @default.
• W2890975982 cites W2060197609 @default.
• W2890975982 cites W2061496561 @default.
• W2890975982 cites W2065139062 @default.
• W2890975982 cites W2074618762 @default.
• W2890975982 cites W2096372976 @default.
• W2890975982 cites W2099731870 @default.
• W2890975982 cites W2100593398 @default.
• W2890975982 cites W2101063972 @default.
• W2890975982 cites W2103498752 @default.
• W2890975982 cites W2103616039 @default.
• W2890975982 cites W2104474203 @default.
• W2890975982 cites W2107277218 @default.
• W2890975982 cites W2119400984 @default.
• W2890975982 cites W2122604763 @default.
• W2890975982 cites W2132260239 @default.
• W2890975982 cites W2132629607 @default.
• W2890975982 cites W2138338247 @default.
• W2890975982 cites W2140517751 @default.
• W2890975982 cites W2143392704 @default.
• W2890975982 cites W2147917253 @default.
• W2890975982 cites W2149133482 @default.
• W2890975982 cites W2152528032 @default.
• W2890975982 cites W2154694904 @default.
• W2890975982 cites W2160011624 @default.
• W2890975982 cites W2160620965 @default.
• W2890975982 cites W2163448677 @default.
• W2890975982 cites W2164642197 @default.
• W2890975982 cites W2165310577 @default.
• W2890975982 cites W2166867592 @default.
• W2890975982 cites W2167080692 @default.
• W2890975982 cites W2195009776 @default.
• W2890975982 cites W2284517327 @default.
• W2890975982 cites W2296269957 @default.
• W2890975982 cites W2408652949 @default.
• W2890975982 cites W2508433652 @default.
• W2890975982 cites W2572413358 @default.
• W2890975982 cites W2603597310 @default.
• W2890975982 cites W2605968187 @default.
• W2890975982 cites W2773836055 @default.
• W2890975982 cites W2775086803 @default.
• W2890975982 cites W4253512500 @default.
• W2890975982 cites W96734778 @default.
• W2890975982 doi "https://doi.org/10.1371/journal.ppat.1007296" @default.
• W2890975982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6171950" @default.
• W2890975982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248143" @default.
• W2890975982 hasPublicationYear "2018" @default.
• W2890975982 type Work @default.
• W2890975982 sameAs 2890975982 @default.
• W2890975982 citedByCount "60" @default.
• W2890975982 countsByYear W28909759822019 @default.
• W2890975982 countsByYear W28909759822020 @default.
• W2890975982 countsByYear W28909759822021 @default.
• W2890975982 countsByYear W28909759822022 @default.
• W2890975982 countsByYear W28909759822023 @default.
• W2890975982 crossrefType "journal-article" @default.
• W2890975982 hasAuthorship W2890975982A5004564974 @default.

• next