FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890977131> ?p ?o ?g. }

• W2890977131 endingPage "56" @default.
• W2890977131 startingPage "49" @default.
• W2890977131 abstract "Aldehyde dehydrogenase 1 (ALDH1) characterizes tumor-initiating cells in solid tumors; however, little is known about its expression in intratumoral stromal cells. Herein, we aimed to dissect its potential dual relevance in prostate cancer (PCa). ALDH1 expression was evaluated immunohistochemically in tumor and stromal cells in primary PCa and metastases. It was correlated to clinico-pathologic parameters, patients’ outcome, and selected proteins (CK5/6, CK14, CK8/18, CK19, EpCAM, Ki-67, E-cadherin, N-cadherin, and vimentin). ALDH1 protein was detected in tumor and stromal cells in 16% and 67% of 348 primary PCa, respectively. Tumor cell ALDH1 expression was associated with advanced T stage (P = 0.009), higher Gleason score (P = 0.016), shorter time to biochemical recurrence (TBR P = 0.010) and CK14 expression (P = 0.023). Stromal cell ALDH1 expression correlated to lower T stage (P = 0.008) and Gleason score (P = 0.016), N0 stage (P = 0.017), and longer TBR (P = 0.017). It occurred to be an independent predictor of good prognosis in the subgroup of d'Amico high-risk patients (multivariate analysis, P = 0.050). ALDH1-positive stromal cells were found in tumors characterized frequently by CK8/18 (P = 0.033) or EpCAM expression (P < 0.001) and rarely by epithelial-mesenchymal transition defined as CK8/18(−)vimentin(+) phenotype (P = 0.003). ALDH1-positive tumor and stromal cells were detected in 33% and 41% of hormone naive lymph node metastases (n = 63), 52% and 24% of castration resistant bone metastases, as well as 89% and 28% of castration resistant visceral metastases (n = 21), respectively. We have determined that contrary to tumor cell ALDH1, the presence of stromal ALDH1 is associated with epithelial phenotype of primary PCa, improved clinical outcome, and is less frequent in PCa metastases. Aldehyde dehydrogenase 1 (ALDH1) characterizes tumor-initiating cells in solid tumors; however, little is known about its expression in intratumoral stromal cells. Herein, we aimed to dissect its potential dual relevance in prostate cancer (PCa). ALDH1 expression was evaluated immunohistochemically in tumor and stromal cells in primary PCa and metastases. It was correlated to clinico-pathologic parameters, patients’ outcome, and selected proteins (CK5/6, CK14, CK8/18, CK19, EpCAM, Ki-67, E-cadherin, N-cadherin, and vimentin). ALDH1 protein was detected in tumor and stromal cells in 16% and 67% of 348 primary PCa, respectively. Tumor cell ALDH1 expression was associated with advanced T stage (P = 0.009), higher Gleason score (P = 0.016), shorter time to biochemical recurrence (TBR P = 0.010) and CK14 expression (P = 0.023). Stromal cell ALDH1 expression correlated to lower T stage (P = 0.008) and Gleason score (P = 0.016), N0 stage (P = 0.017), and longer TBR (P = 0.017). It occurred to be an independent predictor of good prognosis in the subgroup of d'Amico high-risk patients (multivariate analysis, P = 0.050). ALDH1-positive stromal cells were found in tumors characterized frequently by CK8/18 (P = 0.033) or EpCAM expression (P < 0.001) and rarely by epithelial-mesenchymal transition defined as CK8/18(−)vimentin(+) phenotype (P = 0.003). ALDH1-positive tumor and stromal cells were detected in 33% and 41% of hormone naive lymph node metastases (n = 63), 52% and 24% of castration resistant bone metastases, as well as 89% and 28% of castration resistant visceral metastases (n = 21), respectively. We have determined that contrary to tumor cell ALDH1, the presence of stromal ALDH1 is associated with epithelial phenotype of primary PCa, improved clinical outcome, and is less frequent in PCa metastases." @default.
• W2890977131 created "2018-09-27" @default.
• W2890977131 creator A5013046055 @default.
• W2890977131 creator A5014047283 @default.
• W2890977131 creator A5038334067 @default.
• W2890977131 creator A5048105827 @default.
• W2890977131 creator A5050818056 @default.
• W2890977131 creator A5088928712 @default.
• W2890977131 creator A5089665691 @default.
• W2890977131 creator A5091587810 @default.
• W2890977131 date "2019-01-01" @default.
• W2890977131 modified "2023-10-18" @default.
• W2890977131 title "ALDH1-positive intratumoral stromal cells indicate differentiated epithelial-like phenotype and good prognosis in prostate cancer" @default.
• W2890977131 cites W1905076687 @default.
• W2890977131 cites W1930565860 @default.
• W2890977131 cites W1967245224 @default.
• W2890977131 cites W2004556090 @default.
• W2890977131 cites W2012619882 @default.
• W2890977131 cites W2023316892 @default.
• W2890977131 cites W2024310585 @default.
• W2890977131 cites W2037066451 @default.
• W2890977131 cites W2051346881 @default.
• W2890977131 cites W2080927137 @default.
• W2890977131 cites W2081562657 @default.
• W2890977131 cites W2098006347 @default.
• W2890977131 cites W2100283268 @default.
• W2890977131 cites W2104447909 @default.
• W2890977131 cites W2105504936 @default.
• W2890977131 cites W2133506852 @default.
• W2890977131 cites W2135943905 @default.
• W2890977131 cites W2137390086 @default.
• W2890977131 cites W2147787153 @default.
• W2890977131 cites W2150479858 @default.
• W2890977131 cites W2159159025 @default.
• W2890977131 cites W2162250780 @default.
• W2890977131 cites W2893237877 @default.
• W2890977131 doi "https://doi.org/10.1016/j.trsl.2018.08.007" @default.
• W2890977131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287243" @default.
• W2890977131 hasPublicationYear "2019" @default.
• W2890977131 type Work @default.
• W2890977131 sameAs 2890977131 @default.
• W2890977131 citedByCount "13" @default.
• W2890977131 countsByYear W28909771312019 @default.
• W2890977131 countsByYear W28909771312020 @default.
• W2890977131 countsByYear W28909771312021 @default.
• W2890977131 countsByYear W28909771312022 @default.
• W2890977131 countsByYear W28909771312023 @default.
• W2890977131 crossrefType "journal-article" @default.
• W2890977131 hasAuthorship W2890977131A5013046055 @default.
• W2890977131 hasAuthorship W2890977131A5014047283 @default.
• W2890977131 hasAuthorship W2890977131A5038334067 @default.
• W2890977131 hasAuthorship W2890977131A5048105827 @default.
• W2890977131 hasAuthorship W2890977131A5050818056 @default.
• W2890977131 hasAuthorship W2890977131A5088928712 @default.
• W2890977131 hasAuthorship W2890977131A5089665691 @default.
• W2890977131 hasAuthorship W2890977131A5091587810 @default.
• W2890977131 hasConcept C121608353 @default.
• W2890977131 hasConcept C126322002 @default.
• W2890977131 hasConcept C142724271 @default.
• W2890977131 hasConcept C143998085 @default.
• W2890977131 hasConcept C147447768 @default.
• W2890977131 hasConcept C16930146 @default.
• W2890977131 hasConcept C198826908 @default.
• W2890977131 hasConcept C204232928 @default.
• W2890977131 hasConcept C2780192828 @default.
• W2890977131 hasConcept C2780849966 @default.
• W2890977131 hasConcept C502942594 @default.
• W2890977131 hasConcept C71924100 @default.
• W2890977131 hasConceptScore W2890977131C121608353 @default.
• W2890977131 hasConceptScore W2890977131C126322002 @default.
• W2890977131 hasConceptScore W2890977131C142724271 @default.
• W2890977131 hasConceptScore W2890977131C143998085 @default.
• W2890977131 hasConceptScore W2890977131C147447768 @default.
• W2890977131 hasConceptScore W2890977131C16930146 @default.
• W2890977131 hasConceptScore W2890977131C198826908 @default.
• W2890977131 hasConceptScore W2890977131C204232928 @default.
• W2890977131 hasConceptScore W2890977131C2780192828 @default.
• W2890977131 hasConceptScore W2890977131C2780849966 @default.
• W2890977131 hasConceptScore W2890977131C502942594 @default.
• W2890977131 hasConceptScore W2890977131C71924100 @default.
• W2890977131 hasFunder F4320310747 @default.
• W2890977131 hasFunder F4320322511 @default.
• W2890977131 hasFunder F4320332161 @default.
• W2890977131 hasLocation W28909771311 @default.
• W2890977131 hasLocation W28909771312 @default.
• W2890977131 hasOpenAccess W2890977131 @default.
• W2890977131 hasPrimaryLocation W28909771311 @default.
• W2890977131 hasRelatedWork W1967497738 @default.
• W2890977131 hasRelatedWork W1989845789 @default.
• W2890977131 hasRelatedWork W2029559096 @default.
• W2890977131 hasRelatedWork W2030684193 @default.
• W2890977131 hasRelatedWork W2085060133 @default.
• W2890977131 hasRelatedWork W2143455778 @default.
• W2890977131 hasRelatedWork W2162663678 @default.
• W2890977131 hasRelatedWork W2399702428 @default.
• W2890977131 hasRelatedWork W2440936673 @default.
• W2890977131 hasRelatedWork W90099573 @default.
• W2890977131 hasVolume "203" @default.

• next