Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890979085> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2890979085 endingPage "256" @default.
- W2890979085 startingPage "256" @default.
- W2890979085 abstract "1122 Genetic polymorphisms in drug-metabolizing genes have been suggested to play an important role in the inter-individual variations in response to chemotherapy among cancer patients. Limited previous studies, most of which had a small sample size and evaluated a single gene effect on clinical outcomes of treatment, have produced inconsistent results. In this study, we evaluated a combined effect of functional polymorphisms in genes encoding five drug-detoxifying enzymes (GSTM1, GSTT1, GSTP1, UGT1A1 and SULT1A1) on overall survival among 951 breast cancer patients who were recruited into the Shanghai Breast Cancer Study during 1996-1998, treated with both surgery and chemotherapy, and genotyped for all five gene polymorphisms. Of them, 148 were deceased during a median follow-up of 5.2 years after diagnosis. The Cox regression model was used to assess the genotype-outcome association. With the exception of GSTP1 polymorphism, no association was observed between overall survival and each individual polymorphism in the GSTT1, GSTM1, SULT1A1, or UGT1A1gene. Individuals homozygous for the GSTP1105Val allele had a 63% reduced risk of decease (RR = 0.37, 95% CI = 0.16, 0.86) as compared with the 105Ile/105Ile genotype. Potential joint effects of all polymorphisms were evaluated by estimating RRs based on the number of variant genotypes in the SULT1A1, UGT1A1, GSTP1, GSTM1, and GSTT1 genes. The adjusted RRs for death were 1.30 (95% CI = 0.90, 1.87) for patients carrying 1 variant gene, 0.91 (95% CI = 0.64,1.30) for patients carrying 2 variant genes, 1.24 (95% CI = 0.82, 1.87) for patients carrying 3 variant genes, and 1.36 (95% CI = 0.55, 3.39) for patients carrying 4 or more variant genes, compared with those with none of these variant genotypes in these genes. These results do not support a strong effect of genetic polymorphisms in these phase II drug-metabolizing enzymes on breast cancer survival." @default.
- W2890979085 created "2018-09-27" @default.
- W2890979085 creator A5005513706 @default.
- W2890979085 creator A5029073714 @default.
- W2890979085 creator A5036760608 @default.
- W2890979085 creator A5041724163 @default.
- W2890979085 creator A5080361653 @default.
- W2890979085 creator A5085657415 @default.
- W2890979085 date "2004-04-01" @default.
- W2890979085 modified "2023-09-24" @default.
- W2890979085 title "Genetic polymorphisms in selected Phase II drug-metabolizing enzymes in relation to breast cancer survival" @default.
- W2890979085 hasPublicationYear "2004" @default.
- W2890979085 type Work @default.
- W2890979085 sameAs 2890979085 @default.
- W2890979085 citedByCount "1" @default.
- W2890979085 countsByYear W28909790852018 @default.
- W2890979085 crossrefType "journal-article" @default.
- W2890979085 hasAuthorship W2890979085A5005513706 @default.
- W2890979085 hasAuthorship W2890979085A5029073714 @default.
- W2890979085 hasAuthorship W2890979085A5036760608 @default.
- W2890979085 hasAuthorship W2890979085A5041724163 @default.
- W2890979085 hasAuthorship W2890979085A5080361653 @default.
- W2890979085 hasAuthorship W2890979085A5085657415 @default.
- W2890979085 hasConcept C104317684 @default.
- W2890979085 hasConcept C121608353 @default.
- W2890979085 hasConcept C126322002 @default.
- W2890979085 hasConcept C135763542 @default.
- W2890979085 hasConcept C143998085 @default.
- W2890979085 hasConcept C180754005 @default.
- W2890979085 hasConcept C2776694085 @default.
- W2890979085 hasConcept C2780122483 @default.
- W2890979085 hasConcept C530470458 @default.
- W2890979085 hasConcept C54355233 @default.
- W2890979085 hasConcept C71924100 @default.
- W2890979085 hasConcept C86803240 @default.
- W2890979085 hasConceptScore W2890979085C104317684 @default.
- W2890979085 hasConceptScore W2890979085C121608353 @default.
- W2890979085 hasConceptScore W2890979085C126322002 @default.
- W2890979085 hasConceptScore W2890979085C135763542 @default.
- W2890979085 hasConceptScore W2890979085C143998085 @default.
- W2890979085 hasConceptScore W2890979085C180754005 @default.
- W2890979085 hasConceptScore W2890979085C2776694085 @default.
- W2890979085 hasConceptScore W2890979085C2780122483 @default.
- W2890979085 hasConceptScore W2890979085C530470458 @default.
- W2890979085 hasConceptScore W2890979085C54355233 @default.
- W2890979085 hasConceptScore W2890979085C71924100 @default.
- W2890979085 hasConceptScore W2890979085C86803240 @default.
- W2890979085 hasOpenAccess W2890979085 @default.
- W2890979085 hasRelatedWork W1969784655 @default.
- W2890979085 hasRelatedWork W2012304005 @default.
- W2890979085 hasRelatedWork W2030822687 @default.
- W2890979085 hasRelatedWork W2035313170 @default.
- W2890979085 hasRelatedWork W2124857649 @default.
- W2890979085 hasRelatedWork W2129813254 @default.
- W2890979085 hasRelatedWork W2150749577 @default.
- W2890979085 hasRelatedWork W2170451142 @default.
- W2890979085 hasRelatedWork W2184402194 @default.
- W2890979085 hasRelatedWork W2213769963 @default.
- W2890979085 hasRelatedWork W2261715538 @default.
- W2890979085 hasRelatedWork W2326117800 @default.
- W2890979085 hasRelatedWork W2360016962 @default.
- W2890979085 hasRelatedWork W2409294246 @default.
- W2890979085 hasRelatedWork W2409864044 @default.
- W2890979085 hasRelatedWork W2567467572 @default.
- W2890979085 hasRelatedWork W2900636165 @default.
- W2890979085 hasRelatedWork W2945144923 @default.
- W2890979085 hasRelatedWork W2974793850 @default.
- W2890979085 hasRelatedWork W2982175551 @default.
- W2890979085 hasVolume "64" @default.
- W2890979085 isParatext "false" @default.
- W2890979085 isRetracted "false" @default.
- W2890979085 magId "2890979085" @default.
- W2890979085 workType "article" @default.