FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890979347> ?p ?o ?g. }

• W2890979347 endingPage "172" @default.
• W2890979347 startingPage "168" @default.
• W2890979347 abstract "ObjectiveTo investigate the radiosensitivity effects of poly ADP-ribose polymerase -1 (PARP-1) inhibitor 3-amion benzamide (3-AB) on the BRCA non-mutant and BRCA mutant breast cancer cells, and to explore the regulatory mechanism of PARP-1 and BRCA in radiation-induced DNA damage repair.MethodsMDA-MB-436 cells and MDA-MB-231 cells were divided into four groups respectively as the control (CTRL), ionizing radiation alone (IR), 3-AB alone (3-AB), and ionizing radiation combined with 3-AB(IR+ 3-AB)group. γ-H2AX foci were detected by immunofluorescence assay. The radiosensitivity of breast cancer cells was evaluated by clonogenic survival assay. The percentage of apoptotic cells was assessed by flow cytometry.ResultsCompared with MDA-MB-231 cells, MDA-MB-436 cells had a higher radiosensitivity and produced more γ-H2AX foci(t=4.57, P<0.05), which was further increased by 3-AB. The DNA damage of MDA-MB-436 cells in the IR+ 3-AB group was the most remarkable (t=3.26, P<0.05). Flow cytometry showed that the cells in the IR+ 3-AB group had the highest rate of apoptosis(t=3.81, P<0.05), and the apoptosis rate of MDA-MB-436 cells was significantly higher than MDA-MB-231 cells(t=2.96, P<0.05).ConclusionsThe radiosensetivity of BRCA mutant cells MDA-MB-436 is significantly higher than that of non-BRCA mutant cells MDA-MB-231. Inhibition of PARP-1 can further increase the apoptosis and radiosensitivity of BRCA-mutant cells by further blocking the repair of DNA single-strand break induced by ionizing radiation.Key words: PARP-1; BRCA mutation; Radiosensitivity; Breast Cancer; DNA break repair" @default.
• W2890979347 created "2018-09-27" @default.
• W2890979347 creator A5001746337 @default.
• W2890979347 creator A5013973657 @default.
• W2890979347 creator A5022236776 @default.
• W2890979347 creator A5035153885 @default.
• W2890979347 creator A5039555407 @default.
• W2890979347 creator A5068392875 @default.
• W2890979347 date "2016-03-25" @default.
• W2890979347 modified "2023-10-14" @default.
• W2890979347 title "Regulatory mechanisms of the radiosensitive effect of PARP-1 inhibitor on breast cancer cells with BRCA mutation" @default.
• W2890979347 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2016.03.002" @default.
• W2890979347 hasPublicationYear "2016" @default.
• W2890979347 type Work @default.
• W2890979347 sameAs 2890979347 @default.
• W2890979347 citedByCount "0" @default.
• W2890979347 crossrefType "journal-article" @default.
• W2890979347 hasAuthorship W2890979347A5001746337 @default.
• W2890979347 hasAuthorship W2890979347A5013973657 @default.
• W2890979347 hasAuthorship W2890979347A5022236776 @default.
• W2890979347 hasAuthorship W2890979347A5035153885 @default.
• W2890979347 hasAuthorship W2890979347A5039555407 @default.
• W2890979347 hasAuthorship W2890979347A5068392875 @default.
• W2890979347 hasConcept C104317684 @default.
• W2890979347 hasConcept C117262875 @default.
• W2890979347 hasConcept C121608353 @default.
• W2890979347 hasConcept C126322002 @default.
• W2890979347 hasConcept C134935766 @default.
• W2890979347 hasConcept C143065580 @default.
• W2890979347 hasConcept C143425029 @default.
• W2890979347 hasConcept C153911025 @default.
• W2890979347 hasConcept C182979987 @default.
• W2890979347 hasConcept C185592680 @default.
• W2890979347 hasConcept C190283241 @default.
• W2890979347 hasConcept C206684579 @default.
• W2890979347 hasConcept C2779138821 @default.
• W2890979347 hasConcept C2780358455 @default.
• W2890979347 hasConcept C502942594 @default.
• W2890979347 hasConcept C509974204 @default.
• W2890979347 hasConcept C54355233 @default.
• W2890979347 hasConcept C552990157 @default.
• W2890979347 hasConcept C553184892 @default.
• W2890979347 hasConcept C55493867 @default.
• W2890979347 hasConcept C58962609 @default.
• W2890979347 hasConcept C71924100 @default.
• W2890979347 hasConcept C81885089 @default.
• W2890979347 hasConcept C82381507 @default.
• W2890979347 hasConcept C86803240 @default.
• W2890979347 hasConcept C96232424 @default.
• W2890979347 hasConceptScore W2890979347C104317684 @default.
• W2890979347 hasConceptScore W2890979347C117262875 @default.
• W2890979347 hasConceptScore W2890979347C121608353 @default.
• W2890979347 hasConceptScore W2890979347C126322002 @default.
• W2890979347 hasConceptScore W2890979347C134935766 @default.
• W2890979347 hasConceptScore W2890979347C143065580 @default.
• W2890979347 hasConceptScore W2890979347C143425029 @default.
• W2890979347 hasConceptScore W2890979347C153911025 @default.
• W2890979347 hasConceptScore W2890979347C182979987 @default.
• W2890979347 hasConceptScore W2890979347C185592680 @default.
• W2890979347 hasConceptScore W2890979347C190283241 @default.
• W2890979347 hasConceptScore W2890979347C206684579 @default.
• W2890979347 hasConceptScore W2890979347C2779138821 @default.
• W2890979347 hasConceptScore W2890979347C2780358455 @default.
• W2890979347 hasConceptScore W2890979347C502942594 @default.
• W2890979347 hasConceptScore W2890979347C509974204 @default.
• W2890979347 hasConceptScore W2890979347C54355233 @default.
• W2890979347 hasConceptScore W2890979347C552990157 @default.
• W2890979347 hasConceptScore W2890979347C553184892 @default.
• W2890979347 hasConceptScore W2890979347C55493867 @default.
• W2890979347 hasConceptScore W2890979347C58962609 @default.
• W2890979347 hasConceptScore W2890979347C71924100 @default.
• W2890979347 hasConceptScore W2890979347C81885089 @default.
• W2890979347 hasConceptScore W2890979347C82381507 @default.
• W2890979347 hasConceptScore W2890979347C86803240 @default.
• W2890979347 hasConceptScore W2890979347C96232424 @default.
• W2890979347 hasIssue "3" @default.
• W2890979347 hasLocation W28909793471 @default.
• W2890979347 hasOpenAccess W2890979347 @default.
• W2890979347 hasPrimaryLocation W28909793471 @default.
• W2890979347 hasRelatedWork W1526547576 @default.
• W2890979347 hasRelatedWork W2061036769 @default.
• W2890979347 hasRelatedWork W2351198489 @default.
• W2890979347 hasRelatedWork W2356405227 @default.
• W2890979347 hasRelatedWork W2364546322 @default.
• W2890979347 hasRelatedWork W2384290802 @default.
• W2890979347 hasRelatedWork W2482397143 @default.
• W2890979347 hasRelatedWork W2543630978 @default.
• W2890979347 hasRelatedWork W2789869728 @default.
• W2890979347 hasRelatedWork W3004605437 @default.
• W2890979347 hasRelatedWork W3007250675 @default.
• W2890979347 hasRelatedWork W3028932433 @default.
• W2890979347 hasRelatedWork W3029084907 @default.
• W2890979347 hasRelatedWork W3029399262 @default.
• W2890979347 hasRelatedWork W3030638720 @default.
• W2890979347 hasRelatedWork W3031613177 @default.
• W2890979347 hasRelatedWork W3031730397 @default.
• W2890979347 hasRelatedWork W3032014490 @default.
• W2890979347 hasRelatedWork W3032292013 @default.

• next