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- W2890980868 abstract "The main phenol in mate and coffee, 5-caffeoylquinic-acid (5-CQA), and its relevant microbial metabolites, dihydrocaffeic (DHCA) and dihydroferulic (DHFA) acids, have shown oxidative-stress protective effects in HepG2 cells. To evaluate possible endothelial-protective effects of the extracts and compounds, endothelial EA.hy926 cells were pre-treated with yerba mate (YME) and green coffee bean (GCBE) phenolic extracts, 5-CQA, DHCA and DHFA and afterwards stressed with tumour-necrosis-factor-alpha (TNF-α). Then oxidative-stress markers and endothelial-nitric-oxide-synthase levels were studied. TNF-α (10 ng/mL, 24 h) depleted reduced glutathione (GSH) and eNOS levels, increased reactive oxygen species (ROS) production, glutathione peroxidase (GPx) and reductase (GR) activities, and protein oxidation (carbonyl groups, CG) in EA.hy926 cells. Pre-treatment with YME, GCBE, 5-CQA, DHCA at certain physiological concentrations, lowered ROS production, recovered depleted GSH, reduced GR and GPx activities, and CG levels, and enhanced eNOS concentration.. YME, GCBE and 5-CQA show antioxidant effects in endothelial cells playing DHCA an important role in such protection; moreover, the extracts, 5-CQA, DHCA and DHFA increased eNOS levels." @default.
- W2890980868 created "2018-09-27" @default.
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- W2890980868 date "2018-09-06" @default.
- W2890980868 modified "2023-10-12" @default.
- W2890980868 title "TNF-α-induced oxidative stress and endothelial dysfunction in EA.hy926 cells is prevented by mate and green coffee extracts, 5-caffeoylquinic acid and its microbial metabolite, dihydrocaffeic acid" @default.
- W2890980868 cites W1665384959 @default.
- W2890980868 cites W1969678037 @default.
- W2890980868 cites W1975149672 @default.
- W2890980868 cites W1979189704 @default.
- W2890980868 cites W1983411407 @default.
- W2890980868 cites W1986060647 @default.
- W2890980868 cites W1987843799 @default.
- W2890980868 cites W1988957559 @default.
- W2890980868 cites W1991690086 @default.
- W2890980868 cites W1992550390 @default.
- W2890980868 cites W1994578159 @default.
- W2890980868 cites W1994870040 @default.
- W2890980868 cites W1995831750 @default.
- W2890980868 cites W1998936301 @default.
- W2890980868 cites W2010738157 @default.
- W2890980868 cites W2011672756 @default.
- W2890980868 cites W2012762425 @default.
- W2890980868 cites W2025302651 @default.
- W2890980868 cites W2026261400 @default.
- W2890980868 cites W2027247255 @default.
- W2890980868 cites W2029837013 @default.
- W2890980868 cites W2031812992 @default.
- W2890980868 cites W2034133454 @default.
- W2890980868 cites W2034789867 @default.
- W2890980868 cites W2036860623 @default.
- W2890980868 cites W2036967846 @default.
- W2890980868 cites W2037820960 @default.
- W2890980868 cites W2039148546 @default.
- W2890980868 cites W2048593303 @default.
- W2890980868 cites W2052635956 @default.
- W2890980868 cites W2052992926 @default.
- W2890980868 cites W2059258612 @default.
- W2890980868 cites W2059323935 @default.
- W2890980868 cites W2059643569 @default.
- W2890980868 cites W2062552036 @default.
- W2890980868 cites W2066472053 @default.
- W2890980868 cites W2072312187 @default.
- W2890980868 cites W2075482644 @default.
- W2890980868 cites W2076522247 @default.
- W2890980868 cites W2079502988 @default.
- W2890980868 cites W2083974519 @default.
- W2890980868 cites W2092915444 @default.
- W2890980868 cites W2094409391 @default.
- W2890980868 cites W2095228276 @default.
- W2890980868 cites W2102069383 @default.
- W2890980868 cites W2105930251 @default.
- W2890980868 cites W2118771910 @default.
- W2890980868 cites W2119572404 @default.
- W2890980868 cites W2123803574 @default.
- W2890980868 cites W2125948273 @default.
- W2890980868 cites W2137201442 @default.
- W2890980868 cites W2139399563 @default.
- W2890980868 cites W2147737133 @default.
- W2890980868 cites W2155375084 @default.
- W2890980868 cites W2156716051 @default.
- W2890980868 cites W2157428203 @default.
- W2890980868 cites W2157479071 @default.
- W2890980868 cites W2160293048 @default.
- W2890980868 cites W2160691931 @default.
- W2890980868 cites W2214272486 @default.
- W2890980868 cites W2313846174 @default.
- W2890980868 cites W2324093938 @default.
- W2890980868 cites W2460416030 @default.
- W2890980868 cites W2487061216 @default.
- W2890980868 cites W2522125811 @default.
- W2890980868 cites W2558558018 @default.
- W2890980868 cites W2586924169 @default.
- W2890980868 cites W2740663395 @default.
- W2890980868 cites W2750273336 @default.
- W2890980868 cites W2770186111 @default.
- W2890980868 cites W4312854939 @default.
- W2890980868 doi "https://doi.org/10.1080/09637486.2018.1505834" @default.
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