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- W2890981519 endingPage "267" @default.
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- W2890981519 abstract "Autophagy is a catabolic program that is responsible for the degradation of dysfunctional or unnecessary proteins and organelles to maintain cellular homeostasis. Mechanistically, it involves the formation of double-membrane autophagosomes that sequester cytoplasmic material and deliver it to lysosomes for degradation. Eventually, the material is recycled back to the cytoplasm. Abnormalities of autophagy often lead to human diseases, such as neurodegeneration and cancer. In the case of cancer, increasing evidence has revealed the paradoxical roles of autophagy in both tumor inhibition and tumor promotion. Here, we summarize the context-dependent role of autophagy and its complicated molecular mechanisms in the hallmarks of cancer. Moreover, we discuss how therapeutics targeting autophagy can counter malignant transformation and tumor progression. Overall, the findings of studies discussed here shed new light on exploiting the complicated mechanisms of the autophagic machinery and relevant small-molecule modulators as potential antitumor agents to improve therapeutic outcomes." @default.
- W2890981519 created "2018-09-27" @default.
- W2890981519 creator A5020042371 @default.
- W2890981519 creator A5021857158 @default.
- W2890981519 creator A5031877346 @default.
- W2890981519 creator A5032337609 @default.
- W2890981519 creator A5032363571 @default.
- W2890981519 creator A5039882986 @default.
- W2890981519 creator A5048086129 @default.
- W2890981519 creator A5078890396 @default.
- W2890981519 creator A5086058702 @default.
- W2890981519 date "2018-01-01" @default.
- W2890981519 modified "2023-10-16" @default.
- W2890981519 title "Autophagy and Hallmarks of Cancer" @default.
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