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- W2890981691 abstract "The endemicity of highly pathogenic avian influenza (HPAI) A(H5N1) viruses in Asia has led to the generation of reassortant H5 strains with novel gene constellations. A newly emerged highly pathogenic avian influenza (HPAI) A(H5Nx) virus caused poultry outbreaks in the Republic of Korea (Korea) from mid-November 2016. Despite control measures on A(H5Nx)-infected farms, the virus still managed to spread widely in Korea, resulting in the culling of more than 32 million poultry birds within a short period of time. Furthermore, the HPAI H5Nx viruses spread to Europe and North America, where they were detected in domestic birds, wild birds. Although the HPAI H5Nx were highly pathogenic in chickens but was less than stellar at inducing remarkable clinical illness in domestic ducks and ferrets, which may allow establishment of the virus in this host. Furthermore, the virus was moderately pathogenic in mice and had limited tissue tropism relative to that of previous HPAI H5N1 viruses. Although these findings minimize the concern that these HPAI A(H5Nx) viruses in its present phenotype would cause human infections, data also indicate that the virus may have the potential to become endemic in domestic poultry, which could alter genetic evolution of pre-existing strains. In circumstance of world spread of the H5Nx virus and co-circulation with previous HPAI H5N1 viruses, studies on detailed virulence factors and pathogenic potentials of novel H5N8 or its reassortants with preexisting H5 viruses were limited. Therefore, in this study, we investigate the detailed virulence factors of HPAI H5Nx virus by comparing with recent HPAI H5N1 (A/EM/Korea/W149/2006, clade 2.2) and evaluated the pathogenic potentials of H5N8 possible reassortants to evolve to cause highly pathogenic viruses in mice model." @default.
- W2890981691 created "2018-09-27" @default.
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- W2890981691 date "2017-01-01" @default.
- W2890981691 modified "2023-09-28" @default.
- W2890981691 title "Virulence and pathogenic potentials of recent Korean H5Nx viruses" @default.
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