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• W2890981794 abstract "Abstract Purpose Spinal cord MRI at ultra-high field is hampered by time-varying magnetic fields associated with the breathing cycle, giving rise to ghosting artifacts in multi-shot acquisitions. Here, we suggest a correction approach based on linking the signal from a respiratory bellows to field changes inside the spinal cord. The information is used to correct the data at the image reconstruction level. Methods The correction was demonstrated in the context of multi-shot T2*-weighted imaging of the cervical spinal cord at 7T. A respiratory trace was acquired during a high-resolution multi-echo gradient-echo sequence, used for structural imaging and quantitative T2* mapping, and a multi-shot EPI time series, as would be suitable for fMRI. The coupling between the trace and the breathing-induced fields was determined by a short calibration scan in each individual. Images were reconstructed with and without trace-based correction. Results In the multi-echo GRE, breathing-induced fields caused severe ghosting in the long echo time images, which led to a systematic underestimation of T2* in the spinal cord. The trace-based correction reduced the ghosting and increased the estimated T2* values. Breathing-related ghosting was also observed in the multi-shot EPI images. The correction largely removed the ghosting, thereby improving the temporal signal-to-noise ratio of the time series. Conclusions Trace-based retrospective correction of breathing-induced field variations can reduce ghosting and improve quantitative metrics in multi-shot structural and functional T2*-weighted imaging of the spinal cord. The method is straightforward to implement and does not rely on sequence modifications or additional hardware beyond a respiratory bellows." @default.
• W2890981794 created "2018-09-27" @default.
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• W2890981794 date "2018-09-05" @default.
• W2890981794 modified "2023-09-23" @default.
• W2890981794 title "Trace-based correction of breathing-induced field fluctuations in T2*-weighted imaging of the spinal cord" @default.
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• W2890981794 doi "https://doi.org/10.1101/406371" @default.
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