Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890987870> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2890987870 endingPage "e18264" @default.
- W2890987870 startingPage "e18264" @default.
- W2890987870 abstract "e18264 Background: The DOACs apixaban, edoxaban, rivaroxaban, dabigatran offer advantageous alternatives for venous thromboembolism (VTE) treatment in cancer patients, however, there lacks a prospective assessment in this population. We conducted a meta-analysis of RCTs comparing these DOACs to controls to evaluate the safety and efficacy of these new agents for patients with active cancer. Methods: We systematically searched PUBMED, EMBASE, Cochrane Reviews, CINAHL and Clinicaltrials.gov. Two authors (CK, IA) screened and reviewed abstracts and full text, with disagreements resolved by third author (AB). Data extracted included major bleeding and clinically relevant nonmajor bleeding for safety; recurrent VTE and VTE death for efficacy. Analyses included Mantel-Haenszel random effects risk ratios (RR); I 2 for heterogeneity; and meta-regression by publication year. Results: Of 2307 records reviewed, 8 RCTs were retained. Pooled analysis yielded safety RR 0.82 (95%CI = 0.56-1.21, I 2 = 44% ) and efficacy RR 0.94 (95%CI = 0.68-1.31; I 2 = 0%). Meta-regression revealed no publication year bias. Conclusions: Current guidelines have not supported the use of DOACs in clinical cancer practice due to the paucity of data in this setting. Our results indicate no differential efficacy and no increased bleeding risk for DOACs in cancer patients. Additional prospective research is required to determine long term effects in subgroups of cancer patientss at higher risk for VTE or bleeding events. [Table: see text]" @default.
- W2890987870 created "2018-09-27" @default.
- W2890987870 creator A5031658471 @default.
- W2890987870 creator A5049387929 @default.
- W2890987870 creator A5065926611 @default.
- W2890987870 date "2017-05-20" @default.
- W2890987870 modified "2023-09-27" @default.
- W2890987870 title "Safety and efficacy of direct oral anticoagulants (DOAC) in cancer patients: Meta-analysis of randomized controlled trials (RCT)." @default.
- W2890987870 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e18264" @default.
- W2890987870 hasPublicationYear "2017" @default.
- W2890987870 type Work @default.
- W2890987870 sameAs 2890987870 @default.
- W2890987870 citedByCount "1" @default.
- W2890987870 countsByYear W28909878702018 @default.
- W2890987870 crossrefType "journal-article" @default.
- W2890987870 hasAuthorship W2890987870A5031658471 @default.
- W2890987870 hasAuthorship W2890987870A5049387929 @default.
- W2890987870 hasAuthorship W2890987870A5065926611 @default.
- W2890987870 hasConcept C121608353 @default.
- W2890987870 hasConcept C126322002 @default.
- W2890987870 hasConcept C168563851 @default.
- W2890987870 hasConcept C177713679 @default.
- W2890987870 hasConcept C2776301958 @default.
- W2890987870 hasConcept C2778661090 @default.
- W2890987870 hasConcept C2778810321 @default.
- W2890987870 hasConcept C2779161974 @default.
- W2890987870 hasConcept C2780290652 @default.
- W2890987870 hasConcept C2780638905 @default.
- W2890987870 hasConcept C2908647359 @default.
- W2890987870 hasConcept C44249647 @default.
- W2890987870 hasConcept C71924100 @default.
- W2890987870 hasConcept C82789193 @default.
- W2890987870 hasConcept C95190672 @default.
- W2890987870 hasConcept C99454951 @default.
- W2890987870 hasConceptScore W2890987870C121608353 @default.
- W2890987870 hasConceptScore W2890987870C126322002 @default.
- W2890987870 hasConceptScore W2890987870C168563851 @default.
- W2890987870 hasConceptScore W2890987870C177713679 @default.
- W2890987870 hasConceptScore W2890987870C2776301958 @default.
- W2890987870 hasConceptScore W2890987870C2778661090 @default.
- W2890987870 hasConceptScore W2890987870C2778810321 @default.
- W2890987870 hasConceptScore W2890987870C2779161974 @default.
- W2890987870 hasConceptScore W2890987870C2780290652 @default.
- W2890987870 hasConceptScore W2890987870C2780638905 @default.
- W2890987870 hasConceptScore W2890987870C2908647359 @default.
- W2890987870 hasConceptScore W2890987870C44249647 @default.
- W2890987870 hasConceptScore W2890987870C71924100 @default.
- W2890987870 hasConceptScore W2890987870C82789193 @default.
- W2890987870 hasConceptScore W2890987870C95190672 @default.
- W2890987870 hasConceptScore W2890987870C99454951 @default.
- W2890987870 hasIssue "15_suppl" @default.
- W2890987870 hasLocation W28909878701 @default.
- W2890987870 hasOpenAccess W2890987870 @default.
- W2890987870 hasPrimaryLocation W28909878701 @default.
- W2890987870 hasRelatedWork W1969889370 @default.
- W2890987870 hasRelatedWork W1991822753 @default.
- W2890987870 hasRelatedWork W2061451084 @default.
- W2890987870 hasRelatedWork W2080961264 @default.
- W2890987870 hasRelatedWork W2130149431 @default.
- W2890987870 hasRelatedWork W2186954303 @default.
- W2890987870 hasRelatedWork W2558821341 @default.
- W2890987870 hasRelatedWork W2796082272 @default.
- W2890987870 hasRelatedWork W2800235600 @default.
- W2890987870 hasRelatedWork W2183661191 @default.
- W2890987870 hasVolume "35" @default.
- W2890987870 isParatext "false" @default.
- W2890987870 isRetracted "false" @default.
- W2890987870 magId "2890987870" @default.
- W2890987870 workType "article" @default.