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- W2890989073 abstract "RNA interference (RNAi)-based therapeutics are approaching clinical approval for genetically defined diseases. Current clinical success is a result of significant innovations in the development of chemical architectures that support sustained, multi-month efficacy in vivo following a single administration. Conjugate-mediated delivery has established itself as the most promising platform for safe and targeted small interfering RNA (siRNA) delivery. Lipophilic conjugates represent a major class of modifications that improve siRNA pharmacokinetics and enable efficacy in a broad range of tissues. Here, we review current literature and define key features and limitations of this approach for in vivo modulation of gene expression." @default.
- W2890989073 created "2018-09-27" @default.
- W2890989073 creator A5002641644 @default.
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- W2890989073 date "2018-06-01" @default.
- W2890989073 modified "2023-10-09" @default.
- W2890989073 title "Improving siRNA Delivery<i>In Vivo</i>Through Lipid Conjugation" @default.
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- W2890989073 doi "https://doi.org/10.1089/nat.2018.0725" @default.
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