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• W289098911 abstract "Resolution of the innate immune response is an active process resulting in a decrease in inflammation and a halt in activation of the innate immune system. Resolution of the immune response is required to prevent prolonged inflammation that can lead to chronic, immune-mediated inflammation and/or autoimmunity. Both intracellular and extracellular events involving the actions of lipid and protein mediators are required for resolution of inflammation. Some of the events involved in the resolution phase of innate immunity include the apoptosis of pro-inflammatory cells, the antiinflammatory (pro-resolution) effects of chemical or lipid mediators, and the adjustment of cytokine levels in order to decrease inflammatory signaling. Various chemical mediators exist that regulate the resolution of the inflammatory response; some promote inflammation while others are considered anti-inflammatory and pro-resolution mediators. The two main types of pro-inflammatory lipid mediators are prostaglandins and leukotrienes. The spontaneous apoptosis of neutrophils is an important step in the resolution phase of innate immunity and a means to safely clear pro-inflammatory cells from the site of injury. By triggering controlled cell death through apoptosis rather than necrosis, the release of harmful intracellular components to the site of injury is avoided. The interaction between all of these effectors to resolve innate immunity is not fully understood, but current literature in the field suggests that all of the components work together to reverse the effects of the innate immune response. Some artificial methods for inhibiting inflammation by mimicking the resolution phase have been developed and are used routinely to treat aberrant inflammation. These include treatments with drugs such as corticosteroids, NSAIDs, and biologics. By regulating apoptosis machinery and other inflammatory signaling in the body, these pharmacological inhibitors of inflammation attempt to stem chronic inflammation and autoimmunity. Chronic inflammation and compromised immunity are not easily treatable, and a current goal in immunology is figuring out how to reduce this by targeting components involved in resolution of the innate immune response." @default.
• W289098911 created "2016-06-24" @default.
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• W289098911 date "2008-01-01" @default.
• W289098911 modified "2023-09-25" @default.
• W289098911 title "The Resolution of Inflammation" @default.
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• W289098911 doi "https://doi.org/10.1007/978-3-7643-7506-5" @default.
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