Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890989168> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2890989168 endingPage "94" @default.
- W2890989168 startingPage "70" @default.
- W2890989168 abstract "Serine protease, Human Neutrophil Elastase (HNE), has been shown to be useful in medical science, however, its over production and malfunctioning may produce devastating effects and cause serious damage to the host. Unfortunately, the present approved drug, sivelestat, only alleviates the symptoms of the diseases caused by malfunction of HNE but not the disease progression. Therefore, there is a crucial need to search potent and safer molecules as elastase inhibitors and to develop better anti-inflammatory drugs in future. In addition, nature is the best architect that may provide a safer future drug candidate as HNEproduction/ activity inhibitor. Since phenolic natural products are already known as antiinflammatory compounds, either by acting as antioxidants or by any other mechanism, thus, this review article summarizes the discovery and elastase inhibitory activity of ∼180 phenolics isolated from diverse natural sources during more than one decade, i.e. 2005-2017. Keywords: Anti-inflammatory compounds, human neutrophil elastase, inhibitory activity, phenolics, secondary metabolites, disease." @default.
- W2890989168 created "2018-09-27" @default.
- W2890989168 creator A5031526840 @default.
- W2890989168 creator A5032510751 @default.
- W2890989168 creator A5034991924 @default.
- W2890989168 creator A5044394497 @default.
- W2890989168 creator A5071057265 @default.
- W2890989168 creator A5072783254 @default.
- W2890989168 creator A5083646661 @default.
- W2890989168 date "2018-12-10" @default.
- W2890989168 modified "2023-09-26" @default.
- W2890989168 title "Natural Phenolics as Inhibitors of the Human Neutrophil Elastase (HNE) Release: An Overview of Natural Anti-inflammatory Discoveries during Recent Years" @default.
- W2890989168 doi "https://doi.org/10.2174/1871523017666180910104946" @default.
- W2890989168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30198444" @default.
- W2890989168 hasPublicationYear "2018" @default.
- W2890989168 type Work @default.
- W2890989168 sameAs 2890989168 @default.
- W2890989168 citedByCount "9" @default.
- W2890989168 countsByYear W28909891682019 @default.
- W2890989168 countsByYear W28909891682020 @default.
- W2890989168 countsByYear W28909891682021 @default.
- W2890989168 countsByYear W28909891682023 @default.
- W2890989168 crossrefType "journal-article" @default.
- W2890989168 hasAuthorship W2890989168A5031526840 @default.
- W2890989168 hasAuthorship W2890989168A5032510751 @default.
- W2890989168 hasAuthorship W2890989168A5034991924 @default.
- W2890989168 hasAuthorship W2890989168A5044394497 @default.
- W2890989168 hasAuthorship W2890989168A5071057265 @default.
- W2890989168 hasAuthorship W2890989168A5072783254 @default.
- W2890989168 hasAuthorship W2890989168A5083646661 @default.
- W2890989168 hasConcept C104317684 @default.
- W2890989168 hasConcept C134897094 @default.
- W2890989168 hasConcept C181199279 @default.
- W2890989168 hasConcept C182220744 @default.
- W2890989168 hasConcept C185592680 @default.
- W2890989168 hasConcept C203014093 @default.
- W2890989168 hasConcept C2776317360 @default.
- W2890989168 hasConcept C2776714187 @default.
- W2890989168 hasConcept C2776914184 @default.
- W2890989168 hasConcept C2777807008 @default.
- W2890989168 hasConcept C2779703632 @default.
- W2890989168 hasConcept C2780035454 @default.
- W2890989168 hasConcept C2781044401 @default.
- W2890989168 hasConcept C2988867146 @default.
- W2890989168 hasConcept C55493867 @default.
- W2890989168 hasConcept C71924100 @default.
- W2890989168 hasConcept C74187038 @default.
- W2890989168 hasConcept C98274493 @default.
- W2890989168 hasConceptScore W2890989168C104317684 @default.
- W2890989168 hasConceptScore W2890989168C134897094 @default.
- W2890989168 hasConceptScore W2890989168C181199279 @default.
- W2890989168 hasConceptScore W2890989168C182220744 @default.
- W2890989168 hasConceptScore W2890989168C185592680 @default.
- W2890989168 hasConceptScore W2890989168C203014093 @default.
- W2890989168 hasConceptScore W2890989168C2776317360 @default.
- W2890989168 hasConceptScore W2890989168C2776714187 @default.
- W2890989168 hasConceptScore W2890989168C2776914184 @default.
- W2890989168 hasConceptScore W2890989168C2777807008 @default.
- W2890989168 hasConceptScore W2890989168C2779703632 @default.
- W2890989168 hasConceptScore W2890989168C2780035454 @default.
- W2890989168 hasConceptScore W2890989168C2781044401 @default.
- W2890989168 hasConceptScore W2890989168C2988867146 @default.
- W2890989168 hasConceptScore W2890989168C55493867 @default.
- W2890989168 hasConceptScore W2890989168C71924100 @default.
- W2890989168 hasConceptScore W2890989168C74187038 @default.
- W2890989168 hasConceptScore W2890989168C98274493 @default.
- W2890989168 hasIssue "2" @default.
- W2890989168 hasLocation W28909891681 @default.
- W2890989168 hasLocation W28909891682 @default.
- W2890989168 hasOpenAccess W2890989168 @default.
- W2890989168 hasPrimaryLocation W28909891681 @default.
- W2890989168 hasRelatedWork W1978982224 @default.
- W2890989168 hasRelatedWork W1998212202 @default.
- W2890989168 hasRelatedWork W2026166983 @default.
- W2890989168 hasRelatedWork W2111604419 @default.
- W2890989168 hasRelatedWork W2134791291 @default.
- W2890989168 hasRelatedWork W2411586275 @default.
- W2890989168 hasRelatedWork W2851380107 @default.
- W2890989168 hasRelatedWork W2886851907 @default.
- W2890989168 hasRelatedWork W3093180754 @default.
- W2890989168 hasRelatedWork W4307373250 @default.
- W2890989168 hasVolume "17" @default.
- W2890989168 isParatext "false" @default.
- W2890989168 isRetracted "false" @default.
- W2890989168 magId "2890989168" @default.
- W2890989168 workType "article" @default.