FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891003634> ?p ?o ?g. }

• W2891003634 abstract "Human campylobacteriosis is considered one of the most common foodborne diseases worldwide with poultry identified as the main source of infection accounting for 50-80% of human cases. Highly virulent Campylobacter spp., positive for the Type VI secretion system (T6SS), which have an increased ability to adhere to and invade the host gastrointestinal epithelium are highly prevalent in poultry. Multidrug resistant strains of bacteria is rapidly evolving and therefore, new antimicrobials to supplement animal feed that are able to control Campylobacter species, are in great need. The work presented herein indicates that a novel phenolic antimicrobial, Auranta 3001, is able to reduce the adhesion and invasion of human intestinal epithelial cells (HCT-8) by two T6SS positive chicken isolates, C. jejuni RC039 (p<0.05) and C. coli RC013 (p<0.001). Exposure of C. jejuni RC039 and C. coli RC013 to Auranta 3001 downregulated the expression of hcp and cetB genes, known as important in the functionality of T6SS. Furthermore, the reduced adhesion and invasion is associated with a significant decrease in bacterial motility of both isolates (p<0.05 – p<0.001) in vitro. Most importantly our in vivo results show that Auranta 3001 is able to reduce cecum colonisation levels from log 8 CFU/ml to log 2 CFU/ml for C. jejuni RC039 and from log 7 CFU/ml to log 2 CFU/ml for C. coli RC013. In conclusion this novel antimicrobial is able to reduce the pathogenic properties of T6SS campylobacters in vitro and also to decrease colonisation in vivo." @default.
• W2891003634 created "2018-09-27" @default.
• W2891003634 creator A5010333833 @default.
• W2891003634 creator A5017241712 @default.
• W2891003634 creator A5020707905 @default.
• W2891003634 creator A5039761484 @default.
• W2891003634 creator A5040891568 @default.
• W2891003634 creator A5052990907 @default.
• W2891003634 creator A5056477894 @default.
• W2891003634 creator A5068094452 @default.
• W2891003634 creator A5083446244 @default.
• W2891003634 creator A5009302538 @default.
• W2891003634 date "2018-09-07" @default.
• W2891003634 modified "2023-10-18" @default.
• W2891003634 title "A Novel Natural Antimicrobial Can Reduce the in vitro and in vivo Pathogenicity of T6SS Positive Campylobacter jejuni and Campylobacter coli Chicken Isolates" @default.
• W2891003634 cites W1490865911 @default.
• W2891003634 cites W1522761057 @default.
• W2891003634 cites W1828268888 @default.
• W2891003634 cites W1975794382 @default.
• W2891003634 cites W1976519206 @default.
• W2891003634 cites W1977075078 @default.
• W2891003634 cites W1977101213 @default.
• W2891003634 cites W1984536951 @default.
• W2891003634 cites W1987336163 @default.
• W2891003634 cites W2004171730 @default.
• W2891003634 cites W2007095789 @default.
• W2891003634 cites W2011425234 @default.
• W2891003634 cites W2020182736 @default.
• W2891003634 cites W2026237278 @default.
• W2891003634 cites W2034080979 @default.
• W2891003634 cites W2049881746 @default.
• W2891003634 cites W2054537765 @default.
• W2891003634 cites W2054811236 @default.
• W2891003634 cites W2055338430 @default.
• W2891003634 cites W2072312585 @default.
• W2891003634 cites W2077150628 @default.
• W2891003634 cites W2078868151 @default.
• W2891003634 cites W2079081483 @default.
• W2891003634 cites W2083175418 @default.
• W2891003634 cites W2096082374 @default.
• W2891003634 cites W2103540045 @default.
• W2891003634 cites W2105815799 @default.
• W2891003634 cites W2106809706 @default.
• W2891003634 cites W2118633319 @default.
• W2891003634 cites W2118803313 @default.
• W2891003634 cites W2126197356 @default.
• W2891003634 cites W2128644132 @default.
• W2891003634 cites W2131968249 @default.
• W2891003634 cites W2143821568 @default.
• W2891003634 cites W2147297292 @default.
• W2891003634 cites W2150517754 @default.
• W2891003634 cites W2154555351 @default.
• W2891003634 cites W2155782337 @default.
• W2891003634 cites W2157177982 @default.
• W2891003634 cites W2158109845 @default.
• W2891003634 cites W2167212817 @default.
• W2891003634 cites W2169733608 @default.
• W2891003634 cites W2185690853 @default.
• W2891003634 cites W2288132107 @default.
• W2891003634 cites W2512344536 @default.
• W2891003634 cites W2514047058 @default.
• W2891003634 cites W2519759363 @default.
• W2891003634 cites W2520679523 @default.
• W2891003634 cites W2567604724 @default.
• W2891003634 cites W2591113798 @default.
• W2891003634 cites W2602344830 @default.
• W2891003634 cites W2604249056 @default.
• W2891003634 cites W2605287328 @default.
• W2891003634 cites W2607465160 @default.
• W2891003634 cites W2608548240 @default.
• W2891003634 cites W2610908946 @default.
• W2891003634 cites W2753651640 @default.
• W2891003634 cites W2790606533 @default.
• W2891003634 doi "https://doi.org/10.3389/fmicb.2018.02139" @default.
• W2891003634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6137164" @default.
• W2891003634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30245680" @default.
• W2891003634 hasPublicationYear "2018" @default.
• W2891003634 type Work @default.
• W2891003634 sameAs 2891003634 @default.
• W2891003634 citedByCount "32" @default.
• W2891003634 countsByYear W28910036342019 @default.
• W2891003634 countsByYear W28910036342020 @default.
• W2891003634 countsByYear W28910036342021 @default.
• W2891003634 countsByYear W28910036342022 @default.
• W2891003634 countsByYear W28910036342023 @default.
• W2891003634 crossrefType "journal-article" @default.
• W2891003634 hasAuthorship W2891003634A5009302538 @default.
• W2891003634 hasAuthorship W2891003634A5010333833 @default.
• W2891003634 hasAuthorship W2891003634A5017241712 @default.
• W2891003634 hasAuthorship W2891003634A5020707905 @default.
• W2891003634 hasAuthorship W2891003634A5039761484 @default.
• W2891003634 hasAuthorship W2891003634A5040891568 @default.
• W2891003634 hasAuthorship W2891003634A5052990907 @default.
• W2891003634 hasAuthorship W2891003634A5056477894 @default.
• W2891003634 hasAuthorship W2891003634A5068094452 @default.
• W2891003634 hasAuthorship W2891003634A5083446244 @default.
• W2891003634 hasBestOaLocation W28910036341 @default.
• W2891003634 hasConcept C104317684 @default.
• W2891003634 hasConcept C150903083 @default.
• W2891003634 hasConcept C202751555 @default.

• next