Matches in SemOpenAlex for { <https://semopenalex.org/work/W28910076> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W28910076 endingPage "7" @default.
- W28910076 startingPage "133" @default.
- W28910076 abstract "The presence of the carcinoembryonic antigen (CEA) gene and CEA expression in the liver was tested to identify their possible roles in the liver metastasis of colorectal carcinoma. The CEA gene in the liver was identified by amplifying the CEA-specific N-terminal domain exon with digoxigenin-dUTP labeling in 16 colorectal carcinomas with liver metastases. Next, CEA expression was tested by immunostaining using the anti-CEA monoclonal antibody (T84.66, ATCC). Liver tissues from 13 stomach cancer patients and 12 colorectal cancer patients without liver metastasis were also tested as control groups. Three grades (<25%, 25-50%, and 50%< or =) were given according to the proportion of positive cells. The CEA gene was amplified in the metastatic tumor cells of the liver (2.6 +/- 0.2, mean grade +/- SEM) and their surrounding hepatocytes (1.5 +/- 0.2) in all cases. CEA expression was found in all metastatic tumor cells and 14 cases of the surrounding hepatocytes. Among the control groups, the CEA gene of the hepatocytes was found in 9 cases each of the colorectal and the stomach cancers that did not exhibit CEA expression. The level of serum CEA was related with the numbers and volume of liver metastases, but not with CEA expression in tumor cells and surrounding hepatocytes. The CEA gene in the metastatic tumor cells, not in the hepatocytes, was closely associated with CEA expression in the surrounding hepatocytes (p<0.01). Although the precise mechanism of CEA gene regulation in hepatocytes remains to be proven, the CEA gene in the metastatic tumor of the liver seems to affect CEA expression in the surrounding hepatocytes facilitating liver metastasis in colorectal carcinoma." @default.
- W28910076 created "2016-06-24" @default.
- W28910076 creator A5010072083 @default.
- W28910076 creator A5010518834 @default.
- W28910076 creator A5052199736 @default.
- W28910076 creator A5063137841 @default.
- W28910076 date "1999-04-30" @default.
- W28910076 modified "2023-09-23" @default.
- W28910076 title "Carcinoembryonic antigen gene and carcinoembryonic antigen expression in the liver metastasis of colorectal carcinoma." @default.
- W28910076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10340466" @default.
- W28910076 hasPublicationYear "1999" @default.
- W28910076 type Work @default.
- W28910076 sameAs 28910076 @default.
- W28910076 citedByCount "4" @default.
- W28910076 crossrefType "journal-article" @default.
- W28910076 hasAuthorship W28910076A5010072083 @default.
- W28910076 hasAuthorship W28910076A5010518834 @default.
- W28910076 hasAuthorship W28910076A5052199736 @default.
- W28910076 hasAuthorship W28910076A5063137841 @default.
- W28910076 hasConcept C121608353 @default.
- W28910076 hasConcept C126322002 @default.
- W28910076 hasConcept C142724271 @default.
- W28910076 hasConcept C147483822 @default.
- W28910076 hasConcept C159654299 @default.
- W28910076 hasConcept C203014093 @default.
- W28910076 hasConcept C204232928 @default.
- W28910076 hasConcept C2776869981 @default.
- W28910076 hasConcept C2777387746 @default.
- W28910076 hasConcept C2779013556 @default.
- W28910076 hasConcept C3019217517 @default.
- W28910076 hasConcept C4224716 @default.
- W28910076 hasConcept C502942594 @default.
- W28910076 hasConcept C526805850 @default.
- W28910076 hasConcept C542903549 @default.
- W28910076 hasConcept C71924100 @default.
- W28910076 hasConceptScore W28910076C121608353 @default.
- W28910076 hasConceptScore W28910076C126322002 @default.
- W28910076 hasConceptScore W28910076C142724271 @default.
- W28910076 hasConceptScore W28910076C147483822 @default.
- W28910076 hasConceptScore W28910076C159654299 @default.
- W28910076 hasConceptScore W28910076C203014093 @default.
- W28910076 hasConceptScore W28910076C204232928 @default.
- W28910076 hasConceptScore W28910076C2776869981 @default.
- W28910076 hasConceptScore W28910076C2777387746 @default.
- W28910076 hasConceptScore W28910076C2779013556 @default.
- W28910076 hasConceptScore W28910076C3019217517 @default.
- W28910076 hasConceptScore W28910076C4224716 @default.
- W28910076 hasConceptScore W28910076C502942594 @default.
- W28910076 hasConceptScore W28910076C526805850 @default.
- W28910076 hasConceptScore W28910076C542903549 @default.
- W28910076 hasConceptScore W28910076C71924100 @default.
- W28910076 hasIssue "2" @default.
- W28910076 hasLocation W289100761 @default.
- W28910076 hasOpenAccess W28910076 @default.
- W28910076 hasPrimaryLocation W289100761 @default.
- W28910076 hasRelatedWork W1995916162 @default.
- W28910076 hasRelatedWork W2051231904 @default.
- W28910076 hasRelatedWork W21636007 @default.
- W28910076 hasRelatedWork W2167760646 @default.
- W28910076 hasRelatedWork W2200764893 @default.
- W28910076 hasRelatedWork W2315324332 @default.
- W28910076 hasRelatedWork W2381416288 @default.
- W28910076 hasRelatedWork W2621041143 @default.
- W28910076 hasRelatedWork W28910076 @default.
- W28910076 hasRelatedWork W75983121 @default.
- W28910076 hasVolume "9" @default.
- W28910076 isParatext "false" @default.
- W28910076 isRetracted "false" @default.
- W28910076 magId "28910076" @default.
- W28910076 workType "article" @default.