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• W2891007938 abstract "Abstract Motivation Multistate protein design addresses real-world challenges, such as multi-specificity design and backbone flexibility, by considering both positive and negative protein states with an ensemble of substates for each. It also presents an enormous challenge to exact algorithms that guarantee the optimal solutions and enable a direct test of mechanistic hypotheses behind models. However, efficient exact algorithms are lacking for multistate protein design. Results We have developed an efficient exact algorithm called interconnected cost function networks (iCFN) for multistate protein design. Its generic formulation allows for a wide array of applications such as stability, affinity and specificity designs while addressing concerns such as global flexibility of protein backbones. iCFN treats each substate design as a weighted constraint satisfaction problem (WCSP) modeled through a CFN; and it solves the coupled WCSPs using novel bounds and a depth-first branch-and-bound search over a tree structure of sequences, substates, and conformations. When iCFN is applied to specificity design of a T-cell receptor, a problem of unprecedented size to exact methods, it drastically reduces search space and running time to make the problem tractable. Moreover, iCFN generates experimentally-agreeing receptor designs with improved accuracy compared with state-of-the-art methods, highlights the importance of modeling backbone flexibility in protein design, and reveals molecular mechanisms underlying binding specificity. Availability and implementation https://shen-lab.github.io/software/iCFN Supplementary information Supplementary data are available at Bioinformatics online." @default.
• W2891007938 created "2018-09-27" @default.
• W2891007938 creator A5057485825 @default.
• W2891007938 creator A5069807825 @default.
• W2891007938 date "2018-09-01" @default.
• W2891007938 modified "2023-09-27" @default.
• W2891007938 title "iCFN: an efficient exact algorithm for multistate protein design" @default.
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• W2891007938 doi "https://doi.org/10.1093/bioinformatics/bty564" @default.
• W2891007938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129278" @default.
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• W2891007938 hasPublicationYear "2018" @default.
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