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• W2891023498 abstract "Reprogramming of neutrophils by malignant cells is well‐described for many types of solid tumors, but data remain scarce for hematological diseases. Chronic lymphocytic leukemia (CLL) is characterized for a deep immune dysregulation mediated by leukemic cells that compromises patient's outcome. Murine models of CLL highlight the relevance of myeloid cells as tumor‐driven reprogramming targets. In our study, we evaluated neutrophil reprogramming by CLL cells. We first show that the proportion of the CD16 high CD62L dim neutrophil subset in peripheral blood of CLL patients is increased compared to age‐matched healthy donors (HD). In vitro , neutrophils from HD cultured in the presence of CLL cells or conditioned media (CM) from CLL cells exhibited a longer lifespan. Depletion of G‐CSF and GM‐CSF from CM partially reversed the protective effect. In addition, the proportion of viable neutrophils that displayed a CD16 high CD62L dim phenotype was increased in the presence of CM from CLL cells, being TGF‐β/IL‐10 responsible for this effect. Altogether, our results describe a novel mechanism through which CLL cells can manipulate neutrophils." @default.
• W2891023498 created "2018-09-27" @default.
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• W2891023498 date "2018-09-29" @default.
• W2891023498 modified "2023-10-15" @default.
• W2891023498 title "Chronic lymphocytic leukemia cells increase neutrophils survival and promote their differentiation into CD16^high CD62L^dim immunosuppressive subset" @default.
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• W2891023498 doi "https://doi.org/10.1002/ijc.31762" @default.
• W2891023498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30178523" @default.
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