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- W2891023528 endingPage "2121" @default.
- W2891023528 startingPage "2110" @default.
- W2891023528 abstract "Metabolic reprogramming is a hallmark of cancer, but most studies focus on the molecular alterations in cancer cells and much less is known on the role of cancer metabolism, from a holistic perspective, for tumor initiation and progression. Increasing epidemiological evidence highlights the tremendous impact that cancer progression has on the host metabolism, especially in cachexia. However, how this benefits the tumor still is not completely understood. Here we review current studies on fatty acid oxidation in tumor cells as a potential therapeutic target in cancer, and how the redistribution of lipids from fat reservoirs to the cancer cell in the micro- and macro-environment impacts tumorigenesis by helping the tumor fulfill its energetic demands at the expense of fat. In this context, we also discuss the critical role of the signaling adaptor p62/Sequestosome 1(SQSTM1) in adipocytes in mediating tumor-induced fat reprograming and the feedback of adipose tissue on tumor aggressiveness via osteopontin and its potential implications in obesity-promoted cancer and fat cachexia. Collectively these studies highlight the importance of the symbiotic collaboration between adipose tissue and tumor to modulate the cancer metabolic fitness." @default.
- W2891023528 created "2018-09-27" @default.
- W2891023528 creator A5008277357 @default.
- W2891023528 creator A5037329333 @default.
- W2891023528 creator A5055799220 @default.
- W2891023528 date "2018-09-02" @default.
- W2891023528 modified "2023-09-23" @default.
- W2891023528 title "The macroenviromental control of cancer metabolism by p62" @default.
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- W2891023528 doi "https://doi.org/10.1080/15384101.2018.1520566" @default.
- W2891023528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6226228" @default.
- W2891023528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30198373" @default.