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- W2891024163 abstract "Abstract Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLNs), yet preserved in SIV + RMs with pharmacologic or natural control of viremia. In healthy uninfected RMs, experimental depletion of CD4 + T cells in combination with dextran sodium sulfate (DSS) is sufficient to reduce ILC frequencies in the MLN. In this setting and in chronic SIV + RMs, IL-7Rα chain expression diminishes on ILC3s in contrast to the IL-18Rα chain expression which remains stable. In HIV-uninfected patients with durable CD4 + T cell deficiency (deemed idiopathic CD4 + lymphopenia), similar ILC deficiencies in blood were observed, collectively identifying determinants of ILC homeostasis in primates and potential mechanisms underlying their depletion in HIV/SIV infection." @default.
- W2891024163 created "2018-09-27" @default.
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- W2891024163 date "2018-09-27" @default.
- W2891024163 modified "2023-10-16" @default.
- W2891024163 title "Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells" @default.
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- W2891024163 doi "https://doi.org/10.1038/s41467-018-05528-3" @default.
- W2891024163 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160474" @default.
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