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- W2891027069 endingPage "2738" @default.
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- W2891027069 abstract "Sepsis and septic shock are the leading causes of death in non-coronary intensive care units worldwide. During sepsis-associated immune dysfunction, the early/hyper-inflammatory phase transitions to a late/hypo-inflammatory phase as sepsis progresses. The majority of sepsis-related deaths occur during the hypo-inflammatory phase. There are no phase-specific therapies currently available for clinical use in sepsis. Metabolic rewiring directs the transition from hyper-inflammatory to hypo-inflammatory immune responses to protect homeostasis during sepsis inflammation, but the mechanisms underlying this immuno-metabolic network are unclear. Here, we review the roles of NAD+ sensing Sirtuin (SIRT) family members in controlling immunometabolic rewiring during the acute systemic inflammatory response associated with sepsis. We discuss individual contributions among family members SIRT 1, 2, 3, 4 and 6 in regulating the metabolic switch between carbohydrate-fueled hyper-inflammation to lipid-fueled hypo-inflammation. We further highlight the role of SIRT1 and SIRT2 as potential druggable targets for promoting immunometabolic homeostasis and increasing sepsis survival." @default.
- W2891027069 created "2018-09-27" @default.
- W2891027069 creator A5004187355 @default.
- W2891027069 creator A5015608522 @default.
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- W2891027069 creator A5048667512 @default.
- W2891027069 creator A5065306258 @default.
- W2891027069 creator A5088641262 @default.
- W2891027069 date "2018-09-13" @default.
- W2891027069 modified "2023-10-06" @default.
- W2891027069 title "Sirtuins and Immuno-Metabolism of Sepsis" @default.
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