Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891028746> ?p ?o ?g. }
- W2891028746 endingPage "237" @default.
- W2891028746 startingPage "221" @default.
- W2891028746 abstract "The building of robust and versatile inorganic scaffolds with artificial metallo-nuclease (AMN) activity is an important goal for bioinorganic, biotechnology, and metallodrug research fields. Here, a new type of AMN combining a tris-(2-pyridylmethyl)amine (TPMA) scaffold with the copper(II) N,N'-phenanthrene chemical nuclease core is reported. In designing these complexes, the stabilization and flexibility of TPMA together with the prominent chemical nuclease activity of copper 1,10-phenanthroline (Phen) were targeted. A second aspect was the opportunity to introduce designer phenazine DNA intercalators (e.g., dipyridophenazine; DPPZ) for improved DNA recognition. Five compounds of formula [Cu(TPMA)(N,N')]2+ (where N,N' is 2,2-bipyridine (Bipy), Phen, 1,10-phenanthroline-5,6-dione (PD), dipyridoquinoxaline (DPQ), or dipyridophenazine (DPPZ)) were developed and characterized by X-ray crystallography. Solution stabilities were studied by continuous-wave EPR (cw-EPR), hyperfine sublevel correlation (HYSCORE), and Davies electron-nuclear double resonance (ENDOR) spectroscopies, which demonstrated preferred geometries in which phenanthrene ligands were coordinated to the copper(II) TPMA core. Complexes with Phen, DPQ, and DPPZ ligands possessed enhanced DNA binding activity, with DPQ and DPPZ compounds showing excellent intercalative effects. These complexes are effective AMNs and analysis with spin-trapping scavengers of reactive oxygen species and DNA repair enzymes with glycosylase/endonuclease activity demonstrated a distinctive DNA oxidation activity compared to classical Sigman- and Fenton-type reagents." @default.
- W2891028746 created "2018-09-27" @default.
- W2891028746 creator A5010144309 @default.
- W2891028746 creator A5014770212 @default.
- W2891028746 creator A5020077354 @default.
- W2891028746 creator A5020296569 @default.
- W2891028746 creator A5021986989 @default.
- W2891028746 creator A5023384150 @default.
- W2891028746 creator A5067024672 @default.
- W2891028746 creator A5068856350 @default.
- W2891028746 creator A5079759207 @default.
- W2891028746 date "2018-11-27" @default.
- W2891028746 modified "2023-10-18" @default.
- W2891028746 title "Polypyridyl‐Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease" @default.
- W2891028746 cites W1510358641 @default.
- W2891028746 cites W1526143887 @default.
- W2891028746 cites W1531981873 @default.
- W2891028746 cites W1560746966 @default.
- W2891028746 cites W1601910626 @default.
- W2891028746 cites W1603675492 @default.
- W2891028746 cites W174291525 @default.
- W2891028746 cites W1938051019 @default.
- W2891028746 cites W1965136161 @default.
- W2891028746 cites W1969360633 @default.
- W2891028746 cites W1970582018 @default.
- W2891028746 cites W1973493626 @default.
- W2891028746 cites W1973832810 @default.
- W2891028746 cites W1974344932 @default.
- W2891028746 cites W1982321678 @default.
- W2891028746 cites W1982419115 @default.
- W2891028746 cites W1984883623 @default.
- W2891028746 cites W1989918489 @default.
- W2891028746 cites W1991661797 @default.
- W2891028746 cites W1996777648 @default.
- W2891028746 cites W2000142063 @default.
- W2891028746 cites W2000733837 @default.
- W2891028746 cites W2001020336 @default.
- W2891028746 cites W2001465992 @default.
- W2891028746 cites W2005036369 @default.
- W2891028746 cites W2010697269 @default.
- W2891028746 cites W2011682937 @default.
- W2891028746 cites W2015153507 @default.
- W2891028746 cites W2018603999 @default.
- W2891028746 cites W2022155519 @default.
- W2891028746 cites W2025234908 @default.
- W2891028746 cites W2030149067 @default.
- W2891028746 cites W2031337819 @default.
- W2891028746 cites W2033044705 @default.
- W2891028746 cites W2043030694 @default.
- W2891028746 cites W2048645097 @default.
- W2891028746 cites W2054373709 @default.
- W2891028746 cites W2056449951 @default.
- W2891028746 cites W2063240291 @default.
- W2891028746 cites W2063397456 @default.
- W2891028746 cites W2068852202 @default.
- W2891028746 cites W2070361679 @default.
- W2891028746 cites W2071153775 @default.
- W2891028746 cites W2080493328 @default.
- W2891028746 cites W2080733065 @default.
- W2891028746 cites W2082340969 @default.
- W2891028746 cites W2083930268 @default.
- W2891028746 cites W2085562385 @default.
- W2891028746 cites W2088150999 @default.
- W2891028746 cites W2089526528 @default.
- W2891028746 cites W2091234017 @default.
- W2891028746 cites W2095084300 @default.
- W2891028746 cites W2125145029 @default.
- W2891028746 cites W2125789393 @default.
- W2891028746 cites W2126826272 @default.
- W2891028746 cites W2129637612 @default.
- W2891028746 cites W2134259738 @default.
- W2891028746 cites W2145549507 @default.
- W2891028746 cites W2146051607 @default.
- W2891028746 cites W2155608255 @default.
- W2891028746 cites W2163865603 @default.
- W2891028746 cites W2410993730 @default.
- W2891028746 cites W2553968901 @default.
- W2891028746 cites W2584407667 @default.
- W2891028746 cites W2617500092 @default.
- W2891028746 cites W2620885771 @default.
- W2891028746 cites W2795920498 @default.
- W2891028746 cites W2810658624 @default.
- W2891028746 cites W2890458122 @default.
- W2891028746 cites W2952631364 @default.
- W2891028746 cites W3139409337 @default.
- W2891028746 cites W4245397386 @default.
- W2891028746 cites W4245950164 @default.
- W2891028746 cites W4246860983 @default.
- W2891028746 cites W4251268600 @default.
- W2891028746 doi "https://doi.org/10.1002/chem.201804084" @default.
- W2891028746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221802" @default.
- W2891028746 hasPublicationYear "2018" @default.
- W2891028746 type Work @default.
- W2891028746 sameAs 2891028746 @default.
- W2891028746 citedByCount "28" @default.
- W2891028746 countsByYear W28910287462018 @default.
- W2891028746 countsByYear W28910287462019 @default.
- W2891028746 countsByYear W28910287462020 @default.