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- W2891030989 abstract "Neuronal connections are initiated by axon targeting to form synapses. However, how the maturation of axon terminals is modulated through interacting with postsynaptic elements remains elusive. In this study, we find that ligand of Numb protein X 1 (Lnx1), a postsynaptic PDZ protein expressed in hippocampal CA3 pyramidal neurons, is essential for mossy fiber (MF) axon targeting during the postnatal period. Lnx1 deletion causes defective synaptic arrangement that leads to aberrant presynaptic terminals. We further identify EphB receptors as novel Lnx1-binding proteins to form a multiprotein complex that is stabilized on the CA3 neuron membrane through preventing proteasome activity. EphB1 and EphB2 are independently required to transduce distinct signals controlling MF pruning and targeting for precise DG-CA3 synapse formation. Furthermore, constitutively active EphB2 kinase rescues structure of the wired MF terminals in Lnx1 mutant mice. Our data thus define a retrograde trans-synaptic regulation required for integration of post- and presynaptic structure that participates in building hippocampal neural circuits during the adolescence period." @default.
- W2891030989 created "2018-09-27" @default.
- W2891030989 creator A5002179447 @default.
- W2891030989 creator A5023151281 @default.
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- W2891030989 creator A5048720137 @default.
- W2891030989 creator A5076801826 @default.
- W2891030989 creator A5089935092 @default.
- W2891030989 date "2018-09-05" @default.
- W2891030989 modified "2023-10-15" @default.
- W2891030989 title "Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1" @default.
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