FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891034037> ?p ?o ?g. }

• W2891034037 endingPage "1164" @default.
• W2891034037 startingPage "1156" @default.
• W2891034037 abstract "Severe acute pancreatitis is a highly lethal disease caused by systemic inflammatory response syndrome, leading to multiple organ failure. We recently showed that histidine-rich glycoprotein (HRG) supplemental therapy ameliorated septic acute respiratory distress syndrome due to unnecessary neutrophil activation and immunothrombosis formation. Here, we evaluated the effect of HRG on lung inflammation followed by pancreatitis in a severe acute pancreatitis mouse model.Mice received intraperitoneal injections of cerulein 7 times (100 μg/kg each) at 1-hour intervals to induce acute pancreatitis. Immediately after the first cerulein injection, phosphate-buffered saline, human serum albumin (20 mg/kg), or HRG (20 mg/kg) was intravenously injected. One hour after the last cerulein injection, phosphate-buffered saline or lipopolysaccharide (5 mg/kg) was intravenously injected into the tail vein. We evaluated lung inflammatory level after pancreatitis.We observed significantly decreased plasma HRG levels in an acute pancreatitis mouse model. Histidine-rich glycoprotein treatment inhibited lung edema and the accumulation of neutrophil in severe acute pancreatitis, but HRG did not directly affect pancreatitis. Moreover, HRG suppressed tumor necrosis factor α, inducible nitric oxide synthase, interleukin 6, and neutrophil elastase mRNA expression and myeloperoxidase activity in the lung.These data suggested that HRG ameliorated lung inflammation secondary to pancreatitis." @default.
• W2891034037 created "2018-09-27" @default.
• W2891034037 creator A5014373106 @default.
• W2891034037 creator A5020720075 @default.
• W2891034037 creator A5046786082 @default.
• W2891034037 creator A5052658056 @default.
• W2891034037 creator A5064725145 @default.
• W2891034037 creator A5069240767 @default.
• W2891034037 creator A5071921056 @default.
• W2891034037 creator A5076699821 @default.
• W2891034037 date "2018-10-01" @default.
• W2891034037 modified "2023-09-26" @default.
• W2891034037 title "Histidine-Rich Glycoprotein Suppresses Hyperinflammatory Responses of Lung in a Severe Acute Pancreatitis Mouse Model" @default.
• W2891034037 cites W1543388250 @default.
• W2891034037 cites W1597312744 @default.
• W2891034037 cites W1951790452 @default.
• W2891034037 cites W1969500782 @default.
• W2891034037 cites W1976588449 @default.
• W2891034037 cites W1979335925 @default.
• W2891034037 cites W2005870919 @default.
• W2891034037 cites W2013042319 @default.
• W2891034037 cites W2015097836 @default.
• W2891034037 cites W2019787203 @default.
• W2891034037 cites W2022580158 @default.
• W2891034037 cites W2025862326 @default.
• W2891034037 cites W2028556625 @default.
• W2891034037 cites W2059330175 @default.
• W2891034037 cites W2066409110 @default.
• W2891034037 cites W2071851474 @default.
• W2891034037 cites W2072878238 @default.
• W2891034037 cites W2085803061 @default.
• W2891034037 cites W2115691934 @default.
• W2891034037 cites W2128255644 @default.
• W2891034037 cites W2129993297 @default.
• W2891034037 cites W2138877156 @default.
• W2891034037 cites W2155318909 @default.
• W2891034037 cites W2158645792 @default.
• W2891034037 cites W2282335105 @default.
• W2891034037 cites W2331697328 @default.
• W2891034037 cites W2408894040 @default.
• W2891034037 cites W2418823672 @default.
• W2891034037 cites W4210998956 @default.
• W2891034037 doi "https://doi.org/10.1097/mpa.0000000000001153" @default.
• W2891034037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6291257" @default.
• W2891034037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192316" @default.
• W2891034037 hasPublicationYear "2018" @default.
• W2891034037 type Work @default.
• W2891034037 sameAs 2891034037 @default.
• W2891034037 citedByCount "10" @default.
• W2891034037 countsByYear W28910340372019 @default.
• W2891034037 countsByYear W28910340372020 @default.
• W2891034037 countsByYear W28910340372021 @default.
• W2891034037 countsByYear W28910340372022 @default.
• W2891034037 crossrefType "journal-article" @default.
• W2891034037 hasAuthorship W2891034037A5014373106 @default.
• W2891034037 hasAuthorship W2891034037A5020720075 @default.
• W2891034037 hasAuthorship W2891034037A5046786082 @default.
• W2891034037 hasAuthorship W2891034037A5052658056 @default.
• W2891034037 hasAuthorship W2891034037A5064725145 @default.
• W2891034037 hasAuthorship W2891034037A5069240767 @default.
• W2891034037 hasAuthorship W2891034037A5071921056 @default.
• W2891034037 hasAuthorship W2891034037A5076699821 @default.
• W2891034037 hasBestOaLocation W28910340371 @default.
• W2891034037 hasConcept C126322002 @default.
• W2891034037 hasConcept C134018914 @default.
• W2891034037 hasConcept C170493617 @default.
• W2891034037 hasConcept C17991360 @default.
• W2891034037 hasConcept C2775967933 @default.
• W2891034037 hasConcept C2776468924 @default.
• W2891034037 hasConcept C2776670229 @default.
• W2891034037 hasConcept C2776731452 @default.
• W2891034037 hasConcept C2776914184 @default.
• W2891034037 hasConcept C2777397205 @default.
• W2891034037 hasConcept C2777593968 @default.
• W2891034037 hasConcept C2777714996 @default.
• W2891034037 hasConcept C71924100 @default.
• W2891034037 hasConceptScore W2891034037C126322002 @default.
• W2891034037 hasConceptScore W2891034037C134018914 @default.
• W2891034037 hasConceptScore W2891034037C170493617 @default.
• W2891034037 hasConceptScore W2891034037C17991360 @default.
• W2891034037 hasConceptScore W2891034037C2775967933 @default.
• W2891034037 hasConceptScore W2891034037C2776468924 @default.
• W2891034037 hasConceptScore W2891034037C2776670229 @default.
• W2891034037 hasConceptScore W2891034037C2776731452 @default.
• W2891034037 hasConceptScore W2891034037C2776914184 @default.
• W2891034037 hasConceptScore W2891034037C2777397205 @default.
• W2891034037 hasConceptScore W2891034037C2777593968 @default.
• W2891034037 hasConceptScore W2891034037C2777714996 @default.
• W2891034037 hasConceptScore W2891034037C71924100 @default.
• W2891034037 hasIssue "9" @default.
• W2891034037 hasLocation W28910340371 @default.
• W2891034037 hasLocation W28910340372 @default.
• W2891034037 hasLocation W28910340373 @default.
• W2891034037 hasLocation W28910340374 @default.
• W2891034037 hasLocation W28910340375 @default.
• W2891034037 hasLocation W28910340376 @default.
• W2891034037 hasLocation W28910340377 @default.
• W2891034037 hasOpenAccess W2891034037 @default.

• next